CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

Lysosomes are degradation and signaling organelles that adapt their biogenesis to meet many different cellular demands; however, it is unknown how lysosomes change their numbers for cell division. Here, we report that the cyclin-dependent kinases CDK4/6 regulate lysosome biogenesis during the cell c...

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Veröffentlicht in:	The Journal of cell biology 2020-08, Vol.219 (8)
Hauptverfasser:	Yin, Qiuyuan, Jian, Youli, Xu, Meng, Huang, Xiahe, Wang, Niya, Liu, Zhifang, Li, Qian, Li, Jinglin, Zhou, Hejiang, Xu, Lin, Wang, Yingchun, Yang, Chonglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Autophagy Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Biochemistry Cell Cycle Cell Nucleus - enzymology Cell Nucleus - genetics Cell Proliferation Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism HCT116 Cells HeLa Cells Hep G2 Cells Humans Lysosomes - enzymology Lysosomes - genetics Organelle Biogenesis Organelles Phosphorylation Proteolysis Signal Transduction
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