The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis

Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic con...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2020-03, Vol.61 (3), p.8-8
Hauptverfasser:	Guo, Chen, Liu, Jinghua, Hao, Peng, Wang, Yuchuan, Sui, Shuangshuang, Li, Linghan, Ying, Ming, Han, Ruifang, Wang, Liming, Li, Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Plant CD11 Antigens - metabolism Cervical Vertebrae Conjunctiva - metabolism Conjunctivitis, Allergic - genetics Conjunctivitis, Allergic - immunology Conjunctivitis, Allergic - metabolism Cornea Cornea - metabolism Cytokines - biosynthesis Disease Models, Animal Down-Regulation Female Janus Kinases - antagonists & inhibitors Janus Kinases - physiology Lymph Nodes - metabolism Mice, Inbred BALB C MicroRNAs - biosynthesis MicroRNAs - genetics Phenotype Plant Extracts Signal Transduction STAT Transcription Factors - antagonists & inhibitors STAT Transcription Factors - physiology STAT3 Transcription Factor - metabolism Thymic Stromal Lymphopoietin
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