Application of exosomes as liquid biopsy in clinical diagnosis
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30–150 nm. They are secreted by multivesicular bodies through exocytosis in live...
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| Veröffentlicht in: | Signal transduction and targeted therapy 2020-08, Vol.5 (1), p.144-144, Article 144 |
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| creator | Zhou, Biting Xu, Kailun Zheng, Xi Chen, Ting Wang, Jian Song, Yongmao Shao, Yingkuan Zheng, Shu |
| description | Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30–150 nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy. |
| doi_str_mv | 10.1038/s41392-020-00258-9 |
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Exosomes are small extracellular vesicles with sizes between 30–150 nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy.</description><identifier>ISSN: 2059-3635</identifier><identifier>ISSN: 2095-9907</identifier><identifier>EISSN: 2059-3635</identifier><identifier>DOI: 10.1038/s41392-020-00258-9</identifier><identifier>PMID: 32747657</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337 ; 631/67/1857 ; Biopsy ; Cancer Research ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - metabolism ; Cell Biology ; Exosomes - metabolism ; Female ; Humans ; Internal Medicine ; Liquid Biopsy ; Male ; Medicine ; Medicine & Public Health ; Neoplasms - diagnosis ; Neoplasms - metabolism ; Oncology ; Pathology ; Pregnancy ; Pregnancy Complications - diagnosis ; Pregnancy Complications - metabolism ; Review ; Review Article ; Transplants</subject><ispartof>Signal transduction and targeted therapy, 2020-08, Vol.5 (1), p.144-144, Article 144</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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| subjects | 631/337 631/67/1857 Biopsy Cancer Research Cardiovascular Diseases - diagnosis Cardiovascular Diseases - metabolism Cell Biology Exosomes - metabolism Female Humans Internal Medicine Liquid Biopsy Male Medicine Medicine & Public Health Neoplasms - diagnosis Neoplasms - metabolism Oncology Pathology Pregnancy Pregnancy Complications - diagnosis Pregnancy Complications - metabolism Review Review Article Transplants |
| title | Application of exosomes as liquid biopsy in clinical diagnosis |
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