Hypoxic tumor microenvironment: Implications for cancer therapy

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and therapeutic resistance in different cancer types. A large number of these effects are mediated by the transcription factor hypox...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2020-07, Vol.245 (13), p.1073-1086
Hauptverfasser:	Roy, Sukanya, Kumaravel, Subhashree, Sharma, Ankith, Duran, Camille L, Bayless, Kayla J, Chakraborty, Sanjukta
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Hypoxia - physiology Cell Respiration - physiology Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Minireview Mitochondria - metabolism Mitochondria - pathology Neoplasms - metabolism Neoplasms - pathology Tumor Microenvironment - physiology
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