Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition

Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR -mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-driven lung cancers remains unknown. Here we analyz...

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Veröffentlicht in:	NPJ precision oncology 2020-08, Vol.4 (1), p.21, Article 21
Hauptverfasser:	Lin, Jessica J., Langenbucher, Adam, Gupta, Pranav, Yoda, Satoshi, Fetter, Isobel J., Rooney, Marguerite, Do, Andrew, Kem, Marina, Chang, Kylie Prutisto, Oh, Audris Y., Chin, Emily, Juric, Dejan, Corcoran, Ryan B., Dagogo-Jack, Ibiayi, Gainor, Justin F., Stone, James R., Lennerz, Jochen K., Lawrence, Michael S., Hata, Aaron N., Mino-Kenudson, Mari, Shaw, Alice T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1612 692/4028/67/1612 Ablation Biopsy Cancer Research Cancer therapies Case Report Chemotherapy Drug resistance Gene Therapy Human Genetics Inhibitor drugs Internal Medicine Kinases Liver Lung cancer Lymphatic system Medicine Medicine & Public Health Metastasis Mutation Oncology Protein expression Targeted cancer therapy Tumors
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