Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016
Young premenopausal women with breast cancer often experience more aggressive disease biology and poorer survival than older women. Diagnostic and therapeutic advances, including human epidermal growth factor receptor 2 (HER2)-directed therapy, may lessen treatment burden and improve survival for th...
Gespeichert in:
| Veröffentlicht in: | Clinical breast cancer 2020-08, Vol.20 (4), p.e410-e422 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e422 |
|---|---|
| container_issue | 4 |
| container_start_page | e410 |
| container_title | Clinical breast cancer |
| container_volume | 20 |
| creator | Thomas, Alexandra Rhoads, Anthony Suhl, Jonathan Conway, Kristin M. Hundley, William G. McNally, Lacey R. Oleson, Jacob Melin, Susan A. Lynch, Charles F. Romitti, Paul A. |
| description | Young premenopausal women with breast cancer often experience more aggressive disease biology and poorer survival than older women. Diagnostic and therapeutic advances, including human epidermal growth factor receptor 2 (HER2)-directed therapy, may lessen treatment burden and improve survival for these young women, but contemporary incidence and survival data by HER2 status are limited.
We identified women aged 20-49 years (n = 68,530) diagnosed with stage I-III breast cancer during 2010-2016 from the United States Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted average annual percent changes in incidence (diagnosis 2010-2016) and 5-year Kaplan-Meier survival curves (diagnosis 2010-2015) were estimated by HER2 and hormone receptor (HR) status and stratified independently by cancer stage and race/ethnicity.
With increasing age decade, proportions of HER2−/HR+ cancer increased, whereas proportions of HER2+/HR+, HER2+/HR−, and HER2−/HR− decreased. The greatest increases in incidence during 2010-2016 were observed for HER2+ among women aged 20-49 years and HER2−/HR− among women aged 20-29 years. Incidence decreased for HER2−/HR− among women aged 40-49 years. Five-year survival was lowest for HER2−/HR− status compared to other receptor-based subtypes among women aged 20-49 years. HER2+ status was more beneficial for 5-year survival than HR+ status among women aged 20-29 years, with the opposite observed among women aged 30-49 years, particularly those aged 40-49 years.
HER2+ breast cancer increased among premenopausal women and was also associated with higher early survival within each HR status. HER2−/HR− cancer also increased among women aged 20-29 years and was associated with lower early survival. Our contemporary data provide important insights to help inform preventive and therapeutic strategies for premenopausal women.
Contemporary data of breast cancer incidence and survival by human epidermal growth factor receptor 2 (HER2) status among premenopausal women are limited. In our analysis of 68,530 women in the Surveillance, Epidemiology, and End Results (SEER) database aged 20-49 years, HER2+ cancer increased in incidence and was also associated with higher early survival within each hormone receptor status. Our findings provide insights to help inform preventive and therapeutic strategies for premenopausal women. |
| doi_str_mv | 10.1016/j.clbc.2020.01.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7398833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1526820920300306</els_id><sourcerecordid>2389209783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-ab13e4152e4135639300b2d4f302ccead23d5dbe72ba43aacf85ae119b229d933</originalsourceid><addsrcrecordid>eNp9UV1rFDEUDWKxtfoHfJA8-uCs-ZjJzogIumzbgYLQVYpPIZPc3WaZSbZJZqX_wJ9thq2lfSlcbi45556b3IPQO0pmlFDxaTvTfadnjDAyIzRH-QKd0IbXBRFCvMx1xURRM9Ico9cxbglhglPyCh1zxua1KNkJ-ts6bQ04DVg5g1dj2Nu96nF3hy_GQTm83GU4DPnqPPg_6QafKZ18wFegYTcVDK-SSmPE1uHffnQbfO0HcPjaZnKGNoDbom1b_D2AigkvVB4WPuPVcnn1ETNCSZGTeIOO1qqP8Pb-PEW_zpY_FxfF5Y_zdvHtstBlVaVCdZRDmT-WE68EbzghHTPlmhOmNSjDuKlMB3PWqZIrpdd1pYDSpmOsMQ3np-jrQXc3dgMYDS4F1ctdsIMKd9IrK58izt7Ijd_LOW_qmk8CH-4Fgr8dISY52Kih75UDP0bJeN3klc_ricoOVB18jAHWD2MokZOFcisnC-VkoSQ0R5mb3j9-4EPLf88y4cuBAHlNewtBRm0nB40NoJM03j6n_w8x3avA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2389209783</pqid></control><display><type>article</type><title>Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Thomas, Alexandra ; Rhoads, Anthony ; Suhl, Jonathan ; Conway, Kristin M. ; Hundley, William G. ; McNally, Lacey R. ; Oleson, Jacob ; Melin, Susan A. ; Lynch, Charles F. ; Romitti, Paul A.</creator><creatorcontrib>Thomas, Alexandra ; Rhoads, Anthony ; Suhl, Jonathan ; Conway, Kristin M. ; Hundley, William G. ; McNally, Lacey R. ; Oleson, Jacob ; Melin, Susan A. ; Lynch, Charles F. ; Romitti, Paul A.</creatorcontrib><description>Young premenopausal women with breast cancer often experience more aggressive disease biology and poorer survival than older women. Diagnostic and therapeutic advances, including human epidermal growth factor receptor 2 (HER2)-directed therapy, may lessen treatment burden and improve survival for these young women, but contemporary incidence and survival data by HER2 status are limited.
We identified women aged 20-49 years (n = 68,530) diagnosed with stage I-III breast cancer during 2010-2016 from the United States Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted average annual percent changes in incidence (diagnosis 2010-2016) and 5-year Kaplan-Meier survival curves (diagnosis 2010-2015) were estimated by HER2 and hormone receptor (HR) status and stratified independently by cancer stage and race/ethnicity.
With increasing age decade, proportions of HER2−/HR+ cancer increased, whereas proportions of HER2+/HR+, HER2+/HR−, and HER2−/HR− decreased. The greatest increases in incidence during 2010-2016 were observed for HER2+ among women aged 20-49 years and HER2−/HR− among women aged 20-29 years. Incidence decreased for HER2−/HR− among women aged 40-49 years. Five-year survival was lowest for HER2−/HR− status compared to other receptor-based subtypes among women aged 20-49 years. HER2+ status was more beneficial for 5-year survival than HR+ status among women aged 20-29 years, with the opposite observed among women aged 30-49 years, particularly those aged 40-49 years.
HER2+ breast cancer increased among premenopausal women and was also associated with higher early survival within each HR status. HER2−/HR− cancer also increased among women aged 20-29 years and was associated with lower early survival. Our contemporary data provide important insights to help inform preventive and therapeutic strategies for premenopausal women.
Contemporary data of breast cancer incidence and survival by human epidermal growth factor receptor 2 (HER2) status among premenopausal women are limited. In our analysis of 68,530 women in the Surveillance, Epidemiology, and End Results (SEER) database aged 20-49 years, HER2+ cancer increased in incidence and was also associated with higher early survival within each hormone receptor status. Our findings provide insights to help inform preventive and therapeutic strategies for premenopausal women.</description><identifier>ISSN: 1526-8209</identifier><identifier>EISSN: 1938-0666</identifier><identifier>DOI: 10.1016/j.clbc.2020.01.014</identifier><identifier>PMID: 32278642</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - metabolism ; Breast - pathology ; Breast neoplasms ; Breast Neoplasms - diagnosis ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Female ; Humans ; Incidence ; Incidence study ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Staging ; Premenopause ; Prognosis ; Receptor, ErbB-2 - analysis ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - analysis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - analysis ; Receptors, Progesterone - metabolism ; Registries ; Retrospective Studies ; SEER Program - statistics & numerical data ; Survival analysis ; United States - epidemiology ; Young Adult</subject><ispartof>Clinical breast cancer, 2020-08, Vol.20 (4), p.e410-e422</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-ab13e4152e4135639300b2d4f302ccead23d5dbe72ba43aacf85ae119b229d933</citedby><cites>FETCH-LOGICAL-c455t-ab13e4152e4135639300b2d4f302ccead23d5dbe72ba43aacf85ae119b229d933</cites><orcidid>0000-0001-8633-966X ; 0000-0001-6510-9638 ; 0000-0001-9022-2229</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clbc.2020.01.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32278642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Alexandra</creatorcontrib><creatorcontrib>Rhoads, Anthony</creatorcontrib><creatorcontrib>Suhl, Jonathan</creatorcontrib><creatorcontrib>Conway, Kristin M.</creatorcontrib><creatorcontrib>Hundley, William G.</creatorcontrib><creatorcontrib>McNally, Lacey R.</creatorcontrib><creatorcontrib>Oleson, Jacob</creatorcontrib><creatorcontrib>Melin, Susan A.</creatorcontrib><creatorcontrib>Lynch, Charles F.</creatorcontrib><creatorcontrib>Romitti, Paul A.</creatorcontrib><title>Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016</title><title>Clinical breast cancer</title><addtitle>Clin Breast Cancer</addtitle><description>Young premenopausal women with breast cancer often experience more aggressive disease biology and poorer survival than older women. Diagnostic and therapeutic advances, including human epidermal growth factor receptor 2 (HER2)-directed therapy, may lessen treatment burden and improve survival for these young women, but contemporary incidence and survival data by HER2 status are limited.
We identified women aged 20-49 years (n = 68,530) diagnosed with stage I-III breast cancer during 2010-2016 from the United States Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted average annual percent changes in incidence (diagnosis 2010-2016) and 5-year Kaplan-Meier survival curves (diagnosis 2010-2015) were estimated by HER2 and hormone receptor (HR) status and stratified independently by cancer stage and race/ethnicity.
With increasing age decade, proportions of HER2−/HR+ cancer increased, whereas proportions of HER2+/HR+, HER2+/HR−, and HER2−/HR− decreased. The greatest increases in incidence during 2010-2016 were observed for HER2+ among women aged 20-49 years and HER2−/HR− among women aged 20-29 years. Incidence decreased for HER2−/HR− among women aged 40-49 years. Five-year survival was lowest for HER2−/HR− status compared to other receptor-based subtypes among women aged 20-49 years. HER2+ status was more beneficial for 5-year survival than HR+ status among women aged 20-29 years, with the opposite observed among women aged 30-49 years, particularly those aged 40-49 years.
HER2+ breast cancer increased among premenopausal women and was also associated with higher early survival within each HR status. HER2−/HR− cancer also increased among women aged 20-29 years and was associated with lower early survival. Our contemporary data provide important insights to help inform preventive and therapeutic strategies for premenopausal women.
Contemporary data of breast cancer incidence and survival by human epidermal growth factor receptor 2 (HER2) status among premenopausal women are limited. In our analysis of 68,530 women in the Surveillance, Epidemiology, and End Results (SEER) database aged 20-49 years, HER2+ cancer increased in incidence and was also associated with higher early survival within each hormone receptor status. Our findings provide insights to help inform preventive and therapeutic strategies for premenopausal women.</description><subject>Adult</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast - pathology</subject><subject>Breast neoplasms</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Incidence study</subject><subject>Kaplan-Meier Estimate</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Premenopause</subject><subject>Prognosis</subject><subject>Receptor, ErbB-2 - analysis</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - analysis</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>SEER Program - statistics & numerical data</subject><subject>Survival analysis</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>1526-8209</issn><issn>1938-0666</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV1rFDEUDWKxtfoHfJA8-uCs-ZjJzogIumzbgYLQVYpPIZPc3WaZSbZJZqX_wJ9thq2lfSlcbi45556b3IPQO0pmlFDxaTvTfadnjDAyIzRH-QKd0IbXBRFCvMx1xURRM9Ico9cxbglhglPyCh1zxua1KNkJ-ts6bQ04DVg5g1dj2Nu96nF3hy_GQTm83GU4DPnqPPg_6QafKZ18wFegYTcVDK-SSmPE1uHffnQbfO0HcPjaZnKGNoDbom1b_D2AigkvVB4WPuPVcnn1ETNCSZGTeIOO1qqP8Pb-PEW_zpY_FxfF5Y_zdvHtstBlVaVCdZRDmT-WE68EbzghHTPlmhOmNSjDuKlMB3PWqZIrpdd1pYDSpmOsMQ3np-jrQXc3dgMYDS4F1ctdsIMKd9IrK58izt7Ijd_LOW_qmk8CH-4Fgr8dISY52Kih75UDP0bJeN3klc_ricoOVB18jAHWD2MokZOFcisnC-VkoSQ0R5mb3j9-4EPLf88y4cuBAHlNewtBRm0nB40NoJM03j6n_w8x3avA</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Thomas, Alexandra</creator><creator>Rhoads, Anthony</creator><creator>Suhl, Jonathan</creator><creator>Conway, Kristin M.</creator><creator>Hundley, William G.</creator><creator>McNally, Lacey R.</creator><creator>Oleson, Jacob</creator><creator>Melin, Susan A.</creator><creator>Lynch, Charles F.</creator><creator>Romitti, Paul A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8633-966X</orcidid><orcidid>https://orcid.org/0000-0001-6510-9638</orcidid><orcidid>https://orcid.org/0000-0001-9022-2229</orcidid></search><sort><creationdate>20200801</creationdate><title>Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016</title><author>Thomas, Alexandra ; Rhoads, Anthony ; Suhl, Jonathan ; Conway, Kristin M. ; Hundley, William G. ; McNally, Lacey R. ; Oleson, Jacob ; Melin, Susan A. ; Lynch, Charles F. ; Romitti, Paul A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-ab13e4152e4135639300b2d4f302ccead23d5dbe72ba43aacf85ae119b229d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast - pathology</topic><topic>Breast neoplasms</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Incidence study</topic><topic>Kaplan-Meier Estimate</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Premenopause</topic><topic>Prognosis</topic><topic>Receptor, ErbB-2 - analysis</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - analysis</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>SEER Program - statistics & numerical data</topic><topic>Survival analysis</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Alexandra</creatorcontrib><creatorcontrib>Rhoads, Anthony</creatorcontrib><creatorcontrib>Suhl, Jonathan</creatorcontrib><creatorcontrib>Conway, Kristin M.</creatorcontrib><creatorcontrib>Hundley, William G.</creatorcontrib><creatorcontrib>McNally, Lacey R.</creatorcontrib><creatorcontrib>Oleson, Jacob</creatorcontrib><creatorcontrib>Melin, Susan A.</creatorcontrib><creatorcontrib>Lynch, Charles F.</creatorcontrib><creatorcontrib>Romitti, Paul A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical breast cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Alexandra</au><au>Rhoads, Anthony</au><au>Suhl, Jonathan</au><au>Conway, Kristin M.</au><au>Hundley, William G.</au><au>McNally, Lacey R.</au><au>Oleson, Jacob</au><au>Melin, Susan A.</au><au>Lynch, Charles F.</au><au>Romitti, Paul A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016</atitle><jtitle>Clinical breast cancer</jtitle><addtitle>Clin Breast Cancer</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>20</volume><issue>4</issue><spage>e410</spage><epage>e422</epage><pages>e410-e422</pages><issn>1526-8209</issn><eissn>1938-0666</eissn><abstract>Young premenopausal women with breast cancer often experience more aggressive disease biology and poorer survival than older women. Diagnostic and therapeutic advances, including human epidermal growth factor receptor 2 (HER2)-directed therapy, may lessen treatment burden and improve survival for these young women, but contemporary incidence and survival data by HER2 status are limited.
We identified women aged 20-49 years (n = 68,530) diagnosed with stage I-III breast cancer during 2010-2016 from the United States Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted average annual percent changes in incidence (diagnosis 2010-2016) and 5-year Kaplan-Meier survival curves (diagnosis 2010-2015) were estimated by HER2 and hormone receptor (HR) status and stratified independently by cancer stage and race/ethnicity.
With increasing age decade, proportions of HER2−/HR+ cancer increased, whereas proportions of HER2+/HR+, HER2+/HR−, and HER2−/HR− decreased. The greatest increases in incidence during 2010-2016 were observed for HER2+ among women aged 20-49 years and HER2−/HR− among women aged 20-29 years. Incidence decreased for HER2−/HR− among women aged 40-49 years. Five-year survival was lowest for HER2−/HR− status compared to other receptor-based subtypes among women aged 20-49 years. HER2+ status was more beneficial for 5-year survival than HR+ status among women aged 20-29 years, with the opposite observed among women aged 30-49 years, particularly those aged 40-49 years.
HER2+ breast cancer increased among premenopausal women and was also associated with higher early survival within each HR status. HER2−/HR− cancer also increased among women aged 20-29 years and was associated with lower early survival. Our contemporary data provide important insights to help inform preventive and therapeutic strategies for premenopausal women.
Contemporary data of breast cancer incidence and survival by human epidermal growth factor receptor 2 (HER2) status among premenopausal women are limited. In our analysis of 68,530 women in the Surveillance, Epidemiology, and End Results (SEER) database aged 20-49 years, HER2+ cancer increased in incidence and was also associated with higher early survival within each hormone receptor status. Our findings provide insights to help inform preventive and therapeutic strategies for premenopausal women.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32278642</pmid><doi>10.1016/j.clbc.2020.01.014</doi><orcidid>https://orcid.org/0000-0001-8633-966X</orcidid><orcidid>https://orcid.org/0000-0001-6510-9638</orcidid><orcidid>https://orcid.org/0000-0001-9022-2229</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1526-8209 |
| ispartof | Clinical breast cancer, 2020-08, Vol.20 (4), p.e410-e422 |
| issn | 1526-8209 1938-0666 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7398833 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breast - pathology Breast neoplasms Breast Neoplasms - diagnosis Breast Neoplasms - epidemiology Breast Neoplasms - pathology Female Humans Incidence Incidence study Kaplan-Meier Estimate Middle Aged Neoplasm Staging Premenopause Prognosis Receptor, ErbB-2 - analysis Receptor, ErbB-2 - metabolism Receptors, Estrogen - analysis Receptors, Estrogen - metabolism Receptors, Progesterone - analysis Receptors, Progesterone - metabolism Registries Retrospective Studies SEER Program - statistics & numerical data Survival analysis United States - epidemiology Young Adult |
| title | Incidence and Survival by Human Epidermal Growth Factor Receptor 2 Status in Young Women With Stage I-III Breast Cancer: SEER, 2010-2016 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A12%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20and%20Survival%20by%20Human%20Epidermal%20Growth%20Factor%20Receptor%202%20Status%20in%20Young%20Women%20With%20Stage%20I-III%20Breast%20Cancer:%20SEER,%202010-2016&rft.jtitle=Clinical%20breast%20cancer&rft.au=Thomas,%20Alexandra&rft.date=2020-08-01&rft.volume=20&rft.issue=4&rft.spage=e410&rft.epage=e422&rft.pages=e410-e422&rft.issn=1526-8209&rft.eissn=1938-0666&rft_id=info:doi/10.1016/j.clbc.2020.01.014&rft_dat=%3Cproquest_pubme%3E2389209783%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2389209783&rft_id=info:pmid/32278642&rft_els_id=S1526820920300306&rfr_iscdi=true |