2D-HELS MS Seq: A General LC-MS-Based Method for Direct and de novo Sequencing of RNA Mixtures with Different Nucleotide Modifications

Mass spectrometry (MS)-based sequencing approaches have been shown to be useful in direct sequencing RNA without the need for a complementary DNA (cDNA) intermediate. However, such approaches are rarely applied as a de novo RNA sequencing method, but used mainly as a tool that can assist in quality...

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Veröffentlicht in:	Journal of visualized experiments 2020-07 (161)
Hauptverfasser:	Zhang, Ning, Shi, Shundi, Yoo, Barney, Yuan, Xiaohong, Li, Wenjia, Zhang, Shenglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Chromatography, Liquid - methods Nucleotides - metabolism RNA - genetics Sequence Analysis, RNA - methods Tandem Mass Spectrometry - methods
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