Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

Age-related macular degeneration (AMD) is a leading cause of blindness with limited effective treatment. Although the pathogenesis of this disease is complex and not fully understood, the oxidative damage caused by excessive reactive oxygen species (ROS) in retinal pigment epithelium (RPE) has been...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-14
Hauptverfasser:	Zhen, Xuechu, Silva, Marta, Jiang, Yizhou, Liu, Linlin, Zhao, Xia, Zheng, Wenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Antidiabetics Apoptosis Autophagy Autophagy - genetics Blindness Cell culture Cytotoxicity Diabetes Diabetes therapy Homeostasis Humans Hydrogen peroxide Hydrogen Peroxide - adverse effects Kinases Macular degeneration Metabolism Metformin Metformin - pharmacology Metformin - therapeutic use Middle Aged Oxidative Stress - genetics Pathogenesis Penicillin Photoreceptors Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Retinal Pigment Epithelium - metabolism Type 2 diabetes
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