Predictors of genetic testing uptake in newly diagnosed breast cancer patients
Background and Objectives Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population. Methods Within a randomized controlled trial of proactive rapid genetic counseling and test...
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| Veröffentlicht in: | Journal of surgical oncology 2020-08, Vol.122 (2), p.134-143 |
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| container_title | Journal of surgical oncology |
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| creator | Ladd, Mary K. Peshkin, Beth N. Isaacs, Claudine Hooker, Gillian Willey, Shawna Valdimarsdottir, Heiddis DeMarco, Tiffani O'Neill, Suzanne Binion, Savannah Schwartz, Marc D. |
| description | Background and Objectives
Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population.
Methods
Within a randomized controlled trial of proactive rapid genetic counseling and testing vs usual care, patients completed a baseline survey within 6 weeks of breast cancer diagnosis but before a definitive survey. We conducted a multinomial logistic regression to identify predictors of GT timing/uptake.
Results
Having discussed GT with a surgeon was a dominant predictor (χ2 (2, N = 320) = 70.13; P |
| doi_str_mv | 10.1002/jso.25956 |
| format | Article |
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Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population.
Methods
Within a randomized controlled trial of proactive rapid genetic counseling and testing vs usual care, patients completed a baseline survey within 6 weeks of breast cancer diagnosis but before a definitive survey. We conducted a multinomial logistic regression to identify predictors of GT timing/uptake.
Results
Having discussed GT with a surgeon was a dominant predictor (χ2 (2, N = 320) = 70.13; P < .0001). Among those who discussed GT with a surgeon, patients who had made a final surgery decision were less likely to receive GT before surgery compared with postsurgically (OR [odds ratio] = 0.24; 95% confidence interval [CI] = 0.12‐0.49) or no testing (OR = 0.28; 95% CI = 0.14‐0.56). Older patients (OR = 0.95; 95% CI = 0.91‐0.99) and participants enrolled in New York/New Jersey (OR = 0.22; 95% CI = 0.07‐0.72) were less likely to be tested compared with receiving results before surgery. Those with higher perceived risk (OR = 1.02; 95% CI = 1.00‐1.03) were more likely to receive results before surgery than to not be tested.
Conclusions
This study highlights the role of patient‐physician communication about GT as well as patient‐level factors that predict presurgical GT.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.25956</identifier><identifier>PMID: 32346886</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>BRCA1 ; BRCA2 ; Breast cancer ; Genetic counseling ; genetic testing ; Health risk assessment ; Patients ; patient‐physician communication ; Surgeons ; Surgery</subject><ispartof>Journal of surgical oncology, 2020-08, Vol.122 (2), p.134-143</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-4fa983ebe3606b4e7aac356f1ffc082464c0b1a8986805dba3c2d1033e29d94b3</citedby><cites>FETCH-LOGICAL-c4436-4fa983ebe3606b4e7aac356f1ffc082464c0b1a8986805dba3c2d1033e29d94b3</cites><orcidid>0000-0002-2735-5413</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.25956$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.25956$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32346886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ladd, Mary K.</creatorcontrib><creatorcontrib>Peshkin, Beth N.</creatorcontrib><creatorcontrib>Isaacs, Claudine</creatorcontrib><creatorcontrib>Hooker, Gillian</creatorcontrib><creatorcontrib>Willey, Shawna</creatorcontrib><creatorcontrib>Valdimarsdottir, Heiddis</creatorcontrib><creatorcontrib>DeMarco, Tiffani</creatorcontrib><creatorcontrib>O'Neill, Suzanne</creatorcontrib><creatorcontrib>Binion, Savannah</creatorcontrib><creatorcontrib>Schwartz, Marc D.</creatorcontrib><creatorcontrib>other members of the Surgery After Genetic Evaluation Study Group</creatorcontrib><title>Predictors of genetic testing uptake in newly diagnosed breast cancer patients</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population.
Methods
Within a randomized controlled trial of proactive rapid genetic counseling and testing vs usual care, patients completed a baseline survey within 6 weeks of breast cancer diagnosis but before a definitive survey. We conducted a multinomial logistic regression to identify predictors of GT timing/uptake.
Results
Having discussed GT with a surgeon was a dominant predictor (χ2 (2, N = 320) = 70.13; P < .0001). Among those who discussed GT with a surgeon, patients who had made a final surgery decision were less likely to receive GT before surgery compared with postsurgically (OR [odds ratio] = 0.24; 95% confidence interval [CI] = 0.12‐0.49) or no testing (OR = 0.28; 95% CI = 0.14‐0.56). Older patients (OR = 0.95; 95% CI = 0.91‐0.99) and participants enrolled in New York/New Jersey (OR = 0.22; 95% CI = 0.07‐0.72) were less likely to be tested compared with receiving results before surgery. Those with higher perceived risk (OR = 1.02; 95% CI = 1.00‐1.03) were more likely to receive results before surgery than to not be tested.
Conclusions
This study highlights the role of patient‐physician communication about GT as well as patient‐level factors that predict presurgical GT.</description><subject>BRCA1</subject><subject>BRCA2</subject><subject>Breast cancer</subject><subject>Genetic counseling</subject><subject>genetic testing</subject><subject>Health risk assessment</subject><subject>Patients</subject><subject>patient‐physician communication</subject><subject>Surgeons</subject><subject>Surgery</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kUFPFDEUxxsikRU88AVMEy9yGHjTdjvtxcQQUQwRE-DcdDpv1q6z7dLOSPbbW1wgYsLpHd4vv_d_-RNyWMNxDcBOljkes7meyx0yq0HLSoNWr8is7FglGg175E3OSwDQWorXZI8zLqRScka-_0jYeTfGlGns6QIDjt7REfPow4JO69H-QuoDDXg3bGjn7SLEjB1tE9o8UmeDw0TXdvQYxnxAdns7ZHz7MPfJzdnn69Ov1cXll_PTTxeVE4LLSvRWK44tcgmyFdhY6_hc9nXfO1BMSOGgra3SSiqYd63ljnU1cI5Md1q0fJ983HrXU7vCzpXbyQ5mnfzKpo2J1pvnm-B_mkX8bRquG8FUEXx4EKR4O5Vvzcpnh8NgA8YpG8a15MAU4wV9_x-6jFMK5T3DRMnaNFpCoY62lEsx54T9U5gazH1LprRk_rZU2Hf_pn8iH2spwMkWuPMDbl42mW9Xl1vlH_s-nSM</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Ladd, Mary K.</creator><creator>Peshkin, Beth N.</creator><creator>Isaacs, Claudine</creator><creator>Hooker, Gillian</creator><creator>Willey, Shawna</creator><creator>Valdimarsdottir, Heiddis</creator><creator>DeMarco, Tiffani</creator><creator>O'Neill, Suzanne</creator><creator>Binion, Savannah</creator><creator>Schwartz, Marc D.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2735-5413</orcidid></search><sort><creationdate>20200801</creationdate><title>Predictors of genetic testing uptake in newly diagnosed breast cancer patients</title><author>Ladd, Mary K. ; Peshkin, Beth N. ; Isaacs, Claudine ; Hooker, Gillian ; Willey, Shawna ; Valdimarsdottir, Heiddis ; DeMarco, Tiffani ; O'Neill, Suzanne ; Binion, Savannah ; Schwartz, Marc D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-4fa983ebe3606b4e7aac356f1ffc082464c0b1a8986805dba3c2d1033e29d94b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>BRCA1</topic><topic>BRCA2</topic><topic>Breast cancer</topic><topic>Genetic counseling</topic><topic>genetic testing</topic><topic>Health risk assessment</topic><topic>Patients</topic><topic>patient‐physician communication</topic><topic>Surgeons</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ladd, Mary K.</creatorcontrib><creatorcontrib>Peshkin, Beth N.</creatorcontrib><creatorcontrib>Isaacs, Claudine</creatorcontrib><creatorcontrib>Hooker, Gillian</creatorcontrib><creatorcontrib>Willey, Shawna</creatorcontrib><creatorcontrib>Valdimarsdottir, Heiddis</creatorcontrib><creatorcontrib>DeMarco, Tiffani</creatorcontrib><creatorcontrib>O'Neill, Suzanne</creatorcontrib><creatorcontrib>Binion, Savannah</creatorcontrib><creatorcontrib>Schwartz, Marc D.</creatorcontrib><creatorcontrib>other members of the Surgery After Genetic Evaluation Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ladd, Mary K.</au><au>Peshkin, Beth N.</au><au>Isaacs, Claudine</au><au>Hooker, Gillian</au><au>Willey, Shawna</au><au>Valdimarsdottir, Heiddis</au><au>DeMarco, Tiffani</au><au>O'Neill, Suzanne</au><au>Binion, Savannah</au><au>Schwartz, Marc D.</au><aucorp>other members of the Surgery After Genetic Evaluation Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of genetic testing uptake in newly diagnosed breast cancer patients</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>122</volume><issue>2</issue><spage>134</spage><epage>143</epage><pages>134-143</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population.
Methods
Within a randomized controlled trial of proactive rapid genetic counseling and testing vs usual care, patients completed a baseline survey within 6 weeks of breast cancer diagnosis but before a definitive survey. We conducted a multinomial logistic regression to identify predictors of GT timing/uptake.
Results
Having discussed GT with a surgeon was a dominant predictor (χ2 (2, N = 320) = 70.13; P < .0001). Among those who discussed GT with a surgeon, patients who had made a final surgery decision were less likely to receive GT before surgery compared with postsurgically (OR [odds ratio] = 0.24; 95% confidence interval [CI] = 0.12‐0.49) or no testing (OR = 0.28; 95% CI = 0.14‐0.56). Older patients (OR = 0.95; 95% CI = 0.91‐0.99) and participants enrolled in New York/New Jersey (OR = 0.22; 95% CI = 0.07‐0.72) were less likely to be tested compared with receiving results before surgery. Those with higher perceived risk (OR = 1.02; 95% CI = 1.00‐1.03) were more likely to receive results before surgery than to not be tested.
Conclusions
This study highlights the role of patient‐physician communication about GT as well as patient‐level factors that predict presurgical GT.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32346886</pmid><doi>10.1002/jso.25956</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2735-5413</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | BRCA1 BRCA2 Breast cancer Genetic counseling genetic testing Health risk assessment Patients patient‐physician communication Surgeons Surgery |
| title | Predictors of genetic testing uptake in newly diagnosed breast cancer patients |
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