The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis
Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives f...
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description | Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p |
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(Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kemka Nguimatio, François Xavier ; Ngadjui, Esther ; Mvondo, Marie Alfrede ; Minko Essono, Stéphane ; Watcho, Pierre</creator><contributor>Haavik, Svein ; Svein Haavik</contributor><creatorcontrib>Kemka Nguimatio, François Xavier ; Ngadjui, Esther ; Mvondo, Marie Alfrede ; Minko Essono, Stéphane ; Watcho, Pierre ; Haavik, Svein ; Svein Haavik</creatorcontrib><description><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/8521831</identifier><identifier>PMID: 32774432</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>17β-Estradiol ; Abdomen ; Angiogenesis ; Animal models ; Animals ; Antioxidants ; Apoptosis ; Avocados ; Birth control ; Cancer ; Endometriosis ; Endometrium ; Ethanol ; Follicles ; Glutathione ; Hyperplasia ; Inflammation ; Lauraceae ; Lesions ; Malondialdehyde ; Medicinal plants ; Menstruation ; Nonsteroidal anti-inflammatory drugs ; Ovaries ; Ovulation ; Peritoneum ; Persea americana ; Progesterone ; Seeds ; Serum levels ; Surgery ; Transplantation ; Transplants & implants ; Uterus ; Womens health</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Stéphane Minko Essono et al.</rights><rights>Copyright © 2020 Stéphane Minko Essono et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Stéphane Minko Essono et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</citedby><cites>FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</cites><orcidid>0000-0002-9342-8000 ; 0000-0001-5022-3091</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397419/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397419/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Haavik, Svein</contributor><contributor>Svein Haavik</contributor><creatorcontrib>Kemka Nguimatio, François Xavier</creatorcontrib><creatorcontrib>Ngadjui, Esther</creatorcontrib><creatorcontrib>Mvondo, Marie Alfrede</creatorcontrib><creatorcontrib>Minko Essono, Stéphane</creatorcontrib><creatorcontrib>Watcho, Pierre</creatorcontrib><title>The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</title><title>Evidence-based complementary and alternative medicine</title><description><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></description><subject>17β-Estradiol</subject><subject>Abdomen</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Avocados</subject><subject>Birth control</subject><subject>Cancer</subject><subject>Endometriosis</subject><subject>Endometrium</subject><subject>Ethanol</subject><subject>Follicles</subject><subject>Glutathione</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Lauraceae</subject><subject>Lesions</subject><subject>Malondialdehyde</subject><subject>Medicinal plants</subject><subject>Menstruation</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Peritoneum</subject><subject>Persea americana</subject><subject>Progesterone</subject><subject>Seeds</subject><subject>Serum levels</subject><subject>Surgery</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Uterus</subject><subject>Womens health</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk9vEzEQxVcIREvhxhlZ4pIK0q7_7Np7QaraAJFSFbVF4mYN9mzjatcO9m5ovhSfEUeJiuDCyZ55P41mnl5RvKblCaVVdcpKVp6qilHF6ZPikEpBp4Ip9fTxL78dFC9Sui9L1kgpnxcHnEkpBGeHxa_bJZLZsAQfOjJ7GCKYgYSWnK2DARvI5AvGhECgx-gMeCCXrutOyGQBY2YR8PiY3CDaRG5GYzClduy6DZl7O-aKzPtVB34g13gXs-iCJ-BtLtMQcoNcrSE68ORi46F3hrisk2sYyGWw2G03mXkbehyiC8mll8WzFrqEr_bvUfH14-z2_PN0cfVpfn62mBoh1DCVghteylq1gvKG8kqaSlQSrWJMYaNow1slmMCqRtPWTFljABRVDLASLedHxYfd3NX4vUdr0GdnOr2Kroe40QGc_lvxbqnvwlpL3mTTmzxgsh8Qw48xX6t7lwx22QwMY9Isu6_quuEyo2__Qe_DGH0-L1OsqUWj5JZ6v6NMDClFbB-XoaXeBkFvg6D3Qcj4ux2-dN7CT_c_-s2OxsxgC39oWmUXS_4bd7y8Aw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Kemka Nguimatio, François Xavier</creator><creator>Ngadjui, Esther</creator><creator>Mvondo, Marie Alfrede</creator><creator>Minko Essono, Stéphane</creator><creator>Watcho, Pierre</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9342-8000</orcidid><orcidid>https://orcid.org/0000-0001-5022-3091</orcidid></search><sort><creationdate>2020</creationdate><title>The Ethanol Extract of Avocado (Persea americana Mill. 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(Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32774432</pmid><doi>10.1155/2020/8521831</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9342-8000</orcidid><orcidid>https://orcid.org/0000-0001-5022-3091</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 17β-Estradiol Abdomen Angiogenesis Animal models Animals Antioxidants Apoptosis Avocados Birth control Cancer Endometriosis Endometrium Ethanol Follicles Glutathione Hyperplasia Inflammation Lauraceae Lesions Malondialdehyde Medicinal plants Menstruation Nonsteroidal anti-inflammatory drugs Ovaries Ovulation Peritoneum Persea americana Progesterone Seeds Serum levels Surgery Transplantation Transplants & implants Uterus Womens health |
title | The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis |
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