The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis

Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-10
Hauptverfasser: Kemka Nguimatio, François Xavier, Ngadjui, Esther, Mvondo, Marie Alfrede, Minko Essono, Stéphane, Watcho, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 10
container_issue 2020
container_start_page 1
container_title Evidence-based complementary and alternative medicine
container_volume 2020
creator Kemka Nguimatio, François Xavier
Ngadjui, Esther
Mvondo, Marie Alfrede
Minko Essono, Stéphane
Watcho, Pierre
description Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p
doi_str_mv 10.1155/2020/8521831
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7397419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2432866937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</originalsourceid><addsrcrecordid>eNqFkk9vEzEQxVcIREvhxhlZ4pIK0q7_7Np7QaraAJFSFbVF4mYN9mzjatcO9m5ovhSfEUeJiuDCyZ55P41mnl5RvKblCaVVdcpKVp6qilHF6ZPikEpBp4Ip9fTxL78dFC9Sui9L1kgpnxcHnEkpBGeHxa_bJZLZsAQfOjJ7GCKYgYSWnK2DARvI5AvGhECgx-gMeCCXrutOyGQBY2YR8PiY3CDaRG5GYzClduy6DZl7O-aKzPtVB34g13gXs-iCJ-BtLtMQcoNcrSE68ORi46F3hrisk2sYyGWw2G03mXkbehyiC8mll8WzFrqEr_bvUfH14-z2_PN0cfVpfn62mBoh1DCVghteylq1gvKG8kqaSlQSrWJMYaNow1slmMCqRtPWTFljABRVDLASLedHxYfd3NX4vUdr0GdnOr2Kroe40QGc_lvxbqnvwlpL3mTTmzxgsh8Qw48xX6t7lwx22QwMY9Isu6_quuEyo2__Qe_DGH0-L1OsqUWj5JZ6v6NMDClFbB-XoaXeBkFvg6D3Qcj4ux2-dN7CT_c_-s2OxsxgC39oWmUXS_4bd7y8Aw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2429649877</pqid></control><display><type>article</type><title>The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kemka Nguimatio, François Xavier ; Ngadjui, Esther ; Mvondo, Marie Alfrede ; Minko Essono, Stéphane ; Watcho, Pierre</creator><contributor>Haavik, Svein ; Svein Haavik</contributor><creatorcontrib>Kemka Nguimatio, François Xavier ; Ngadjui, Esther ; Mvondo, Marie Alfrede ; Minko Essono, Stéphane ; Watcho, Pierre ; Haavik, Svein ; Svein Haavik</creatorcontrib><description><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/8521831</identifier><identifier>PMID: 32774432</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>17β-Estradiol ; Abdomen ; Angiogenesis ; Animal models ; Animals ; Antioxidants ; Apoptosis ; Avocados ; Birth control ; Cancer ; Endometriosis ; Endometrium ; Ethanol ; Follicles ; Glutathione ; Hyperplasia ; Inflammation ; Lauraceae ; Lesions ; Malondialdehyde ; Medicinal plants ; Menstruation ; Nonsteroidal anti-inflammatory drugs ; Ovaries ; Ovulation ; Peritoneum ; Persea americana ; Progesterone ; Seeds ; Serum levels ; Surgery ; Transplantation ; Transplants &amp; implants ; Uterus ; Womens health</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Stéphane Minko Essono et al.</rights><rights>Copyright © 2020 Stéphane Minko Essono et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Stéphane Minko Essono et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</citedby><cites>FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</cites><orcidid>0000-0002-9342-8000 ; 0000-0001-5022-3091</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397419/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397419/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Haavik, Svein</contributor><contributor>Svein Haavik</contributor><creatorcontrib>Kemka Nguimatio, François Xavier</creatorcontrib><creatorcontrib>Ngadjui, Esther</creatorcontrib><creatorcontrib>Mvondo, Marie Alfrede</creatorcontrib><creatorcontrib>Minko Essono, Stéphane</creatorcontrib><creatorcontrib>Watcho, Pierre</creatorcontrib><title>The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</title><title>Evidence-based complementary and alternative medicine</title><description><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></description><subject>17β-Estradiol</subject><subject>Abdomen</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Avocados</subject><subject>Birth control</subject><subject>Cancer</subject><subject>Endometriosis</subject><subject>Endometrium</subject><subject>Ethanol</subject><subject>Follicles</subject><subject>Glutathione</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Lauraceae</subject><subject>Lesions</subject><subject>Malondialdehyde</subject><subject>Medicinal plants</subject><subject>Menstruation</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Peritoneum</subject><subject>Persea americana</subject><subject>Progesterone</subject><subject>Seeds</subject><subject>Serum levels</subject><subject>Surgery</subject><subject>Transplantation</subject><subject>Transplants &amp; implants</subject><subject>Uterus</subject><subject>Womens health</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk9vEzEQxVcIREvhxhlZ4pIK0q7_7Np7QaraAJFSFbVF4mYN9mzjatcO9m5ovhSfEUeJiuDCyZ55P41mnl5RvKblCaVVdcpKVp6qilHF6ZPikEpBp4Ip9fTxL78dFC9Sui9L1kgpnxcHnEkpBGeHxa_bJZLZsAQfOjJ7GCKYgYSWnK2DARvI5AvGhECgx-gMeCCXrutOyGQBY2YR8PiY3CDaRG5GYzClduy6DZl7O-aKzPtVB34g13gXs-iCJ-BtLtMQcoNcrSE68ORi46F3hrisk2sYyGWw2G03mXkbehyiC8mll8WzFrqEr_bvUfH14-z2_PN0cfVpfn62mBoh1DCVghteylq1gvKG8kqaSlQSrWJMYaNow1slmMCqRtPWTFljABRVDLASLedHxYfd3NX4vUdr0GdnOr2Kroe40QGc_lvxbqnvwlpL3mTTmzxgsh8Qw48xX6t7lwx22QwMY9Isu6_quuEyo2__Qe_DGH0-L1OsqUWj5JZ6v6NMDClFbB-XoaXeBkFvg6D3Qcj4ux2-dN7CT_c_-s2OxsxgC39oWmUXS_4bd7y8Aw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Kemka Nguimatio, François Xavier</creator><creator>Ngadjui, Esther</creator><creator>Mvondo, Marie Alfrede</creator><creator>Minko Essono, Stéphane</creator><creator>Watcho, Pierre</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9342-8000</orcidid><orcidid>https://orcid.org/0000-0001-5022-3091</orcidid></search><sort><creationdate>2020</creationdate><title>The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</title><author>Kemka Nguimatio, François Xavier ; Ngadjui, Esther ; Mvondo, Marie Alfrede ; Minko Essono, Stéphane ; Watcho, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-743c30768f41391357c5457ed8228e98193f8424e56ecf628dccaa8182ae54f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>17β-Estradiol</topic><topic>Abdomen</topic><topic>Angiogenesis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Avocados</topic><topic>Birth control</topic><topic>Cancer</topic><topic>Endometriosis</topic><topic>Endometrium</topic><topic>Ethanol</topic><topic>Follicles</topic><topic>Glutathione</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>Lauraceae</topic><topic>Lesions</topic><topic>Malondialdehyde</topic><topic>Medicinal plants</topic><topic>Menstruation</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Peritoneum</topic><topic>Persea americana</topic><topic>Progesterone</topic><topic>Seeds</topic><topic>Serum levels</topic><topic>Surgery</topic><topic>Transplantation</topic><topic>Transplants &amp; implants</topic><topic>Uterus</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemka Nguimatio, François Xavier</creatorcontrib><creatorcontrib>Ngadjui, Esther</creatorcontrib><creatorcontrib>Mvondo, Marie Alfrede</creatorcontrib><creatorcontrib>Minko Essono, Stéphane</creatorcontrib><creatorcontrib>Watcho, Pierre</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemka Nguimatio, François Xavier</au><au>Ngadjui, Esther</au><au>Mvondo, Marie Alfrede</au><au>Minko Essono, Stéphane</au><au>Watcho, Pierre</au><au>Haavik, Svein</au><au>Svein Haavik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.]]></abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32774432</pmid><doi>10.1155/2020/8521831</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9342-8000</orcidid><orcidid>https://orcid.org/0000-0001-5022-3091</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1741-427X
ispartof Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-10
issn 1741-427X
1741-4288
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7397419
source PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection
subjects 17β-Estradiol
Abdomen
Angiogenesis
Animal models
Animals
Antioxidants
Apoptosis
Avocados
Birth control
Cancer
Endometriosis
Endometrium
Ethanol
Follicles
Glutathione
Hyperplasia
Inflammation
Lauraceae
Lesions
Malondialdehyde
Medicinal plants
Menstruation
Nonsteroidal anti-inflammatory drugs
Ovaries
Ovulation
Peritoneum
Persea americana
Progesterone
Seeds
Serum levels
Surgery
Transplantation
Transplants & implants
Uterus
Womens health
title The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A17%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Ethanol%20Extract%20of%20Avocado%20(Persea%20americana%20Mill.%20(Lauraceae))%20Seeds%20Successfully%20Induces%20Implant%20Regression%20and%20Restores%20Ovarian%20Dynamic%20in%20a%20Rat%20Model%20of%20Endometriosis&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Kemka%20Nguimatio,%20Fran%C3%A7ois%20Xavier&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=10&rft.pages=1-10&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2020/8521831&rft_dat=%3Cproquest_pubme%3E2432866937%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2429649877&rft_id=info:pmid/32774432&rfr_iscdi=true