Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload

The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease. Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models. We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aor...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-8
Hauptverfasser:	Kim, Gun Jik, Kim, Inkyeom, Lee, Eunjo, Jung, Hanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysms Angiotensin Angiotensin receptors Animal models Animals Aorta Aorta - metabolism Aorta - pathology Attenuation Beta blockers Blood pressure Cardiovascular diseases Constriction, Pathologic Coronary vessels Endothelium Extracellular matrix Fibrosis Gelatinase A Gelatinase B Gene expression Gene Expression Regulation - drug effects Health aspects Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histones Hypertension Hypertension - metabolism Hypertension - pathology Immunohistochemistry Inhibitors Laboratory animals Male Overloading Polymerase chain reaction Rats Rats, Sprague-Dawley Receptors Rodents Smooth muscle Thorax Vascular Remodeling
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