A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface

Compartmentalization of macromolecules is a ubiquitous molecular mechanism that drives numerous cellular functions. The appropriate organization of enzymes in space and time enables the precise transmission and integration of intracellular signals. Molecular scaffolds constrain signaling enzymes to...

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Veröffentlicht in:	The Journal of biological chemistry 2020-07, Vol.295 (31), p.10749-10765
Hauptverfasser:	Gabrovsek, Laura, Collins, Kerrie B., Aggarwal, Stacey, Saunders, Lauren M., Lau, Ho-Tak, Suh, Danny, Sancak, Yasemin, Trapnell, Cole, Ong, Shao-En, Smith, F. Donelson, Scott, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - genetics A Kinase Anchor Proteins - metabolism A-kinase anchoring proteins (AKAPs) Autoantigens - genetics Autoantigens - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Electron Transport Chain Complex Proteins - biosynthesis HEK293 Cells Humans intracellular compartmentalization local signaling complexes mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membranes - metabolism mitochondrial respiratory chain complex molecular scaffold Poly(A)-Binding Protein I - genetics Poly(A)-Binding Protein I - metabolism Protein Biosynthesis protein kinase A (PKA) protein kinases Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA-Seq RNA–protein interaction Second Messenger Systems Signal Transduction SS-B Antigen translation regulation
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