Anti-Diabetic Atherosclerosis by Inhibiting High Glucose-Induced Vascular Smooth Muscle Cell Proliferation via Pin1/BRD4 Pathway

Background and purpose. Vascular smooth muscle cells (VSMC) proliferation and migration is the important pathological process of diabetic atherosclerosis. Bromine domain protein 4 (BRD4) is involved in cell proliferation and inflammatory disease. Pin1 enhances BRD4 stability and its transcriptional...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-13
Hauptverfasser:	Peng, Feng, Chai, Dajun, Xu, Chang-Sheng, Zhang, Meijin, Wu, Yuansheng, Lin, Jinxiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antidiabetics Apolipoproteins Atherosclerosis Atherosclerosis - therapy Cell adhesion & migration Cell cycle Cell growth Cell Proliferation Coronary vessels Dextrose Diabetes Genetic vectors Glucose Glucose - metabolism Humans Kinases Male Membranes Mice Muscle, Smooth, Vascular - physiopathology Nuclear Proteins Phosphorylation Polymerase chain reaction Product information Proteins RNA polymerase Smooth muscle Transcription Factors
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