Abyssinone V-4′ Methyl Ether, a Flavanone Isolated from Erythrina droogmansiana, Exhibits Cytotoxic Effects on Human Breast Cancer Cells by Induction of Apoptosis and Suppression of Invasion

Abyssinone V-4′ methyl ether (AVME) isolated from Erythrina droogmansiana was recently reported to exhibit anti-mammary tumor effect in mice. The present work was therefore aimed at elucidating its cellular and molecular mechanisms. To achieve our goal, the cytotoxicity of AVME against tumoral and n...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-14
Hauptverfasser:	Ndinteh, Derek Tantoh, Creczynski-Pasa, Tânia Beatriz, Bishayee, Anupam, Talla, Emmanuel, Kenmogne, Larissa Vanelle, Cisilotto, Julia, Gbaweng Yaya, Abel Joël, Zingue, Stephane, Njamen, Dieudonné
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 protein Bcl-x protein Breast cancer Cancer cells Cancer therapies Caspase-3 Caspase-9 Cell culture Cell cycle Cell death Cytotoxicity Erythrina Exhibitions Fibroblasts Flow cytometry Mammary gland Medical equipment and supplies industry Medical test kit industry Membrane potential Metabolites Metalloproteinase Methyl ether Mitochondria Molecular modelling Reactive oxygen species Regulatory proteins Tumor cell lines Tumors
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