A review of the main histopathological findings in coronavirus disease 2019
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse...
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| Veröffentlicht in: | Human pathology 2020-11, Vol.105, p.74-83 |
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| creator | Vasquez-Bonilla, Walter O. Orozco, Roberto Argueta, Víctor Sierra, Manuel Zambrano, Lysien I. Muñoz-Lara, Fausto López-Molina, Dennis Salomón Arteaga-Livias, Kovy Grimes, Zachary Bryce, Clare Paniz-Mondolfi, Alberto Rodríguez-Morales, Alfonso J. |
| description | Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings. |
| doi_str_mv | 10.1016/j.humpath.2020.07.023 |
| format | Article |
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SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2020.07.023</identifier><identifier>PMID: 32750378</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Autopsy ; Biopsy ; Blood Vessels - pathology ; Central Nervous System - pathology ; Coronaviruses ; COVID-19 ; COVID-19 - pathology ; Female ; Histopathology ; Humans ; Kidney - pathology ; Lung - pathology ; Lymph Nodes - pathology ; Male ; Middle Aged ; Middle East respiratory syndrome ; Myocardium - pathology ; Pathology ; Respiratory diseases ; SARS-CoV-2 ; Thromboembolism - pathology ; Viruses</subject><ispartof>Human pathology, 2020-11, Vol.105, p.74-83</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><rights>2020 Elsevier Inc. All rights reserved. 2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-c57bc29262e17d425600e9d28ee2a67fd6413a374e2671baee153bcb14a513b33</citedby><cites>FETCH-LOGICAL-c561t-c57bc29262e17d425600e9d28ee2a67fd6413a374e2671baee153bcb14a513b33</cites><orcidid>0000-0003-2388-215X ; 0000-0003-1221-0518 ; 0000-0001-9773-2192 ; 0000-0003-1259-1736 ; 0000-0002-6456-4521 ; 0000-0003-1372-8933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2020.07.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32750378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasquez-Bonilla, Walter O.</creatorcontrib><creatorcontrib>Orozco, Roberto</creatorcontrib><creatorcontrib>Argueta, Víctor</creatorcontrib><creatorcontrib>Sierra, Manuel</creatorcontrib><creatorcontrib>Zambrano, Lysien I.</creatorcontrib><creatorcontrib>Muñoz-Lara, Fausto</creatorcontrib><creatorcontrib>López-Molina, Dennis Salomón</creatorcontrib><creatorcontrib>Arteaga-Livias, Kovy</creatorcontrib><creatorcontrib>Grimes, Zachary</creatorcontrib><creatorcontrib>Bryce, Clare</creatorcontrib><creatorcontrib>Paniz-Mondolfi, Alberto</creatorcontrib><creatorcontrib>Rodríguez-Morales, Alfonso J.</creatorcontrib><title>A review of the main histopathological findings in coronavirus disease 2019</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsy</subject><subject>Biopsy</subject><subject>Blood Vessels - pathology</subject><subject>Central Nervous System - pathology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - pathology</subject><subject>Female</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Kidney - pathology</subject><subject>Lung - pathology</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Middle East respiratory syndrome</subject><subject>Myocardium - pathology</subject><subject>Pathology</subject><subject>Respiratory diseases</subject><subject>SARS-CoV-2</subject><subject>Thromboembolism - pathology</subject><subject>Viruses</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EotuFnwCKxIXLpmM7tpMLqKqgoFbiAmfLcSYbrxJ7sZNF_Pt6tUsFXHoZH-bNm3n-CHlDoaRA5dWuHJZpb-ahZMCgBFUC48_IigrONjVv2HOyAqjkpqZKXZDLlHYAlIpKvCQXnCkBXNUrcnddRDw4_FWEvpgHLCbjfDG4NIejeRjD1lkzFr3znfPbVOSuDTF4c3BxSUXnEpqEBQPavCIvejMmfH1-1-TH50_fb75s7r_dfr25vt9YIemcq2ota5hkSFVXMSEBsOlYjciMVH0nK8oNVxUyqWhrEHOm1ra0MoLylvM1-XDy3S_thJ1FP0cz6n10k4m_dTBO_9vxbtDbcNCKN6KpVDZ4fzaI4eeCadaTSxbH0XgMS9Ks4iCrmuU71uTdf9JdWKLP8bJKMgBGm6OhOKlsDClF7B-PoaCPuPROn3HpIy4NSmdcee7t30kep_7wyYKPJwHm_8yYok7WobfYuYh21l1wT6x4AAuKqMY</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Vasquez-Bonilla, Walter O.</creator><creator>Orozco, Roberto</creator><creator>Argueta, Víctor</creator><creator>Sierra, Manuel</creator><creator>Zambrano, Lysien I.</creator><creator>Muñoz-Lara, Fausto</creator><creator>López-Molina, Dennis Salomón</creator><creator>Arteaga-Livias, Kovy</creator><creator>Grimes, Zachary</creator><creator>Bryce, Clare</creator><creator>Paniz-Mondolfi, Alberto</creator><creator>Rodríguez-Morales, Alfonso J.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2388-215X</orcidid><orcidid>https://orcid.org/0000-0003-1221-0518</orcidid><orcidid>https://orcid.org/0000-0001-9773-2192</orcidid><orcidid>https://orcid.org/0000-0003-1259-1736</orcidid><orcidid>https://orcid.org/0000-0002-6456-4521</orcidid><orcidid>https://orcid.org/0000-0003-1372-8933</orcidid></search><sort><creationdate>20201101</creationdate><title>A review of the main histopathological findings in coronavirus disease 2019</title><author>Vasquez-Bonilla, Walter O. ; Orozco, Roberto ; Argueta, Víctor ; Sierra, Manuel ; Zambrano, Lysien I. ; Muñoz-Lara, Fausto ; López-Molina, Dennis Salomón ; Arteaga-Livias, Kovy ; Grimes, Zachary ; Bryce, Clare ; Paniz-Mondolfi, Alberto ; Rodríguez-Morales, Alfonso J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-c57bc29262e17d425600e9d28ee2a67fd6413a374e2671baee153bcb14a513b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsy</topic><topic>Biopsy</topic><topic>Blood Vessels - pathology</topic><topic>Central Nervous System - pathology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - pathology</topic><topic>Female</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Kidney - pathology</topic><topic>Lung - pathology</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Middle East respiratory syndrome</topic><topic>Myocardium - pathology</topic><topic>Pathology</topic><topic>Respiratory diseases</topic><topic>SARS-CoV-2</topic><topic>Thromboembolism - pathology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasquez-Bonilla, Walter O.</creatorcontrib><creatorcontrib>Orozco, Roberto</creatorcontrib><creatorcontrib>Argueta, Víctor</creatorcontrib><creatorcontrib>Sierra, Manuel</creatorcontrib><creatorcontrib>Zambrano, Lysien I.</creatorcontrib><creatorcontrib>Muñoz-Lara, Fausto</creatorcontrib><creatorcontrib>López-Molina, Dennis Salomón</creatorcontrib><creatorcontrib>Arteaga-Livias, Kovy</creatorcontrib><creatorcontrib>Grimes, Zachary</creatorcontrib><creatorcontrib>Bryce, Clare</creatorcontrib><creatorcontrib>Paniz-Mondolfi, Alberto</creatorcontrib><creatorcontrib>Rodríguez-Morales, Alfonso J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasquez-Bonilla, Walter O.</au><au>Orozco, Roberto</au><au>Argueta, Víctor</au><au>Sierra, Manuel</au><au>Zambrano, Lysien I.</au><au>Muñoz-Lara, Fausto</au><au>López-Molina, Dennis Salomón</au><au>Arteaga-Livias, Kovy</au><au>Grimes, Zachary</au><au>Bryce, Clare</au><au>Paniz-Mondolfi, Alberto</au><au>Rodríguez-Morales, Alfonso J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review of the main histopathological findings in coronavirus disease 2019</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>105</volume><spage>74</spage><epage>83</epage><pages>74-83</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. 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| subjects | Adult Aged Aged, 80 and over Autopsy Biopsy Blood Vessels - pathology Central Nervous System - pathology Coronaviruses COVID-19 COVID-19 - pathology Female Histopathology Humans Kidney - pathology Lung - pathology Lymph Nodes - pathology Male Middle Aged Middle East respiratory syndrome Myocardium - pathology Pathology Respiratory diseases SARS-CoV-2 Thromboembolism - pathology Viruses |
| title | A review of the main histopathological findings in coronavirus disease 2019 |
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