TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss

Early pregnancy loss affects ∼15% of all implantation-confirmed human conceptions. However, evolutionarily conserved molecular mechanisms that regulate self-renewal of trophoblast progenitors and their association with early pregnancy loss are poorly understood. Here, we provide evidence that transc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-07, Vol.117 (30), p.17864-17875
Hauptverfasser:	Saha, Biswarup, Ganguly, Avishek, Home, Pratik, Bhattacharya, Bhaswati, Ray, Soma, Ghosh, Ananya, Rumi, M. A. Karim, Marsh, Courtney, French, Valerie A., Gunewardena, Sumedha, Paul, Soumen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - etiology Abortion, Habitual - metabolism Abortion, Spontaneous - etiology Abortion, Spontaneous - metabolism Animals Biological Sciences Biomarkers Cell cycle Cell Self Renewal - genetics Cell self-renewal Developmental stages Disease Models, Animal Disease Susceptibility DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo Implantation Embryonic Development - genetics Embryos Female Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Developmental Gestation Humans Immunohistochemistry Implantation Lethality Mice Molecular modelling Muscle Proteins - genetics Muscle Proteins - metabolism Placenta Placenta - metabolism Pregnancy Progenitor cells Signal transduction Signaling Stem cell transplantation Stem cells TEA Domain Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Trophoblasts - cytology Trophoblasts - metabolism Yes-associated protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!