Peptidylglycine α-amidating monooxygenase is required for atrial secretory granule formation

The discovery of atrial secretory granules and the natriuretic peptides stored in them identified the atrium as an endocrine organ. Although neither atrial nor brain natriuretic peptide (ANP, BNP) is amidated, the major membrane protein in atrial granules is peptidylglycine α-amidating monooxygenase...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-07, Vol.117 (30), p.17820-17831
Hauptverfasser:	Bäck, Nils, Luxmi, Raj, Powers, Kathryn G., Mains, Richard E., Eipper, Betty A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidine-Lyases - genetics Amidine-Lyases - metabolism Animals Atria Atrial Natriuretic Factor - metabolism Atrium Biological Sciences Biosynthesis Brain natriuretic peptide Cardiomyocytes Cre recombinase Cytoplasmic Granules - metabolism Cytoplasmic Granules - ultrastructure Endoplasmic reticulum Gene dosage Gene Expression Golgi apparatus Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Granular materials Granule cells Heart Atria - metabolism Lysosomes - metabolism Lysosomes - ultrastructure Membrane proteins Mice Mice, Knockout Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Monocytes - metabolism Muscle Cells - metabolism Myocytes Peptides Peptidylglycine monooxygenase Proteins Secretion Secretory vesicles Secretory Vesicles - metabolism Secretory Vesicles - ultrastructure
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