In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy

Objective To select potential molecules that can target viral spike proteins, which may potentially interrupt the interaction between the human angiotension-converting enzyme 2 (ACE2) receptor and viral spike protein by virtual screening. Methods The three-dimensional (3D)-coordinate file of the rec...

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Veröffentlicht in:	Chinese journal of integrative medicine 2020-09, Vol.26 (9), p.663-669
Hauptverfasser:	Wei, Tian-zi, Wang, Hao, Wu, Xue-qing, Lu, Yi, Guan, Sheng-hui, Dong, Feng-quan, Dong, Chen-le, Zhu, Gu-li, Bao, Yu-zhou, Zhang, Jian, Wang, Guan-yu, Li, Hai-ying
Format:	Artikel
Sprache:	eng
Schlagworte:	China Computer Simulation Coronavirus Infections - diagnosis Coronavirus Infections - drug therapy COVID-19 Drug Repositioning - methods Drugs, Chinese Herbal - pharmacology Glycoproteins - drug effects Glycoproteins - metabolism Humans Imaging, Three-Dimensional Mass Screening - methods Medicine Medicine & Public Health Molecular Docking Simulation - methods Original Original Article Pandemics Peptidyl-Dipeptidase A - drug effects Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Protein Binding United States United States Food and Drug Administration
Online-Zugang:	Volltext
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