Management of Chemotherapy-Induced Nausea and Vomiting (CINV): A Short Review on the Role of Netupitant-Palonosetron (NEPA)

Antineoplastic drugs may induce several side effects, including chemotherapy-induced nausea and vomiting (CINV). Two neurotransmitters play a central role in mediating the emetic response: serotonin acting on the 5HT3 receptor and the substance P targeting the NK1 receptor. Indeed, a combination of...

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Veröffentlicht in:	Core evidence 2020-01, Vol.15, p.21-29
Hauptverfasser:	Lorusso, Vito, Russo, Anna, Giotta, Francesco, Codega, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic drugs Carboplatin Chemotherapy Cisplatin Cyclophosphamide Dexamethasone Drug dosages Motion sickness Nausea Neurotransmitters Patients Pharmacokinetics Pregnancy Prophylaxis Review Risk factors Risk groups Serotonin Serotonin S3 receptors Substance P Vomiting
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