Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis

Hotspot p53 mutant proteins often gain novel functions in promoting tumor metastases. However, the molecular mechanisms by which mutant p53 exerts gain-of-function in cancer are not totally understood. In this study, we demonstrate that hotspot mutant p53, p53-R273H, promotes cell scattering growth...

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Veröffentlicht in:	Cell death & disease 2020-07, Vol.11 (7), p.595-595, Article 595
Hauptverfasser:	Sun, Shengnan, Chen, Hu, Sun, Lijuan, Wang, Miao, Wu, Xianqiang, Xiao, Zhi-Xiong Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/84/2176 692/420/755 AKT protein Animals Antibodies Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cadherins - genetics Cadherins - metabolism Cell adhesion & migration Cell Biology Cell Culture Cell Line, Tumor Cell migration Cell Movement - genetics Down-Regulation - genetics E-cadherin Epidermal growth factor receptors ErbB Receptors - metabolism Female Forkhead Box Protein O1 - metabolism FOXO1 protein Gene Expression Regulation, Neoplastic Humans Immunology Kruppel-Like Factor 6 - genetics Kruppel-Like Factor 6 - metabolism Life Sciences Metastases Metastasis Mice, Inbred BALB C Mice, Nude Molecular modelling Mutants Mutation - genetics Neoplasm Metastasis p53 Protein Proto-Oncogene Proteins c-akt - metabolism Transcription, Genetic Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Zinc finger proteins
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