The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 and culminating in the development of ARDS. The innate immune response to infection of type II alveolar epithelial cel...

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Veröffentlicht in:	Life sciences (1973) 2020-10, Vol.258, p.118166-118166, Article 118166
Hauptverfasser:	Morris, Gerwyn, Bortolasci, Chiara C., Puri, Basant K., Olive, Lisa, Marx, Wolfgang, O'Neil, Adrienne, Athan, Eugene, Carvalho, Andre F., Maes, Michael, Walder, Ken, Berk, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - pathology Alveoli Animals Apoptosis Betacoronavirus - immunology Betacoronavirus - physiology Cell activation Chemokines Chromatin Coronavirus Infections - complications Coronavirus Infections - immunology Coronavirus Infections - physiopathology Coronavirus Infections - therapy COVID-19 Cytokine storm Cytokines Endothelial cells Environmental factors Epithelial cells Epithelium Helper cells Histones HMGB1 protein Humans Immune response Immune system Immunity, Innate Infections Inflammation Inflammation - etiology Inflammation - immunology Inflammation - physiopathology Inflammation - therapy Innate immunity Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Lymphopenia Macrophage Activation Macrophages Macrophages, Alveolar - immunology Macrophages, Alveolar - pathology Mitochondrial DNA Neutrophil Activation Neutrophils Pandemics Phenotypes Platelet Activation Platelets Pneumocytes Pneumonia, Viral - complications Pneumonia, Viral - immunology Pneumonia, Viral - physiopathology Pneumonia, Viral - therapy Priming Pyroptosis Reactive oxygen species Recruitment Respiratory Distress Syndrome - etiology Respiratory Distress Syndrome - immunology Respiratory Distress Syndrome - physiopathology Respiratory Distress Syndrome - therapy Respiratory infection Review SARS-CoV-2 Sepsis Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Thrombophilia - etiology Thrombophilia - immunology Thrombophilia - physiopathology Thrombophilia - therapy Toll-like receptors Treatment
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