Substrate stiffness regulates primary hepatocyte functions

Liver fibrosis occurs as a consequence of chronic injuries from viral infections, metabolic disorders, and alcohol abuse. Fibrotic liver microenvironment (LME) is characterized by excessive deposition and aberrant turnover of extracellular matrix proteins, which leads to increased tissue stiffness....

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (99), p.80956-80966
Hauptverfasser:	Natarajan, Vaishaali, Berglund, Eric J., Chen, Dorothy X., Kidambi, Srivatsan
Format:	Artikel
Sprache:	eng
Schlagworte:	Culture Fibrosis Liver Progressions Silicone resins Stiffness Substrates Transporter
Online-Zugang:	Volltext
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