The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the cano...
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| Veröffentlicht in: | Iranian biomedical journal 2020-09, Vol.24 (5), p.269-275 |
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| description | Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseases, including cancers, neurodegenerative disorders, skin and bone diseases, and heart deficiencies. Therefore, Wnt/β-Catenin signal transduction is a potential clinical target for the treatment of not only human cancers but also some other human chronic diseases. Here, some recent results including those from my laboratory highlighting the role of Wnt/β-Catenin signal transduction in human cancers will be reviewed. After a brief overview on canonical Wnt signaling and introducing some critical β-Catenin/T-cell factor-target genes, the interaction of canonical Wnt signaling with some common human cancers will be discussed. In the end, the different segments of the aforesaid signaling pathway, which have been considered as targets for clinical purposes, will be scrutinized. |
| doi_str_mv | 10.29252/ibj.24.5.264 |
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Box 14155-6455, Tehran, Iran</creatorcontrib><description>Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseases, including cancers, neurodegenerative disorders, skin and bone diseases, and heart deficiencies. Therefore, Wnt/β-Catenin signal transduction is a potential clinical target for the treatment of not only human cancers but also some other human chronic diseases. Here, some recent results including those from my laboratory highlighting the role of Wnt/β-Catenin signal transduction in human cancers will be reviewed. After a brief overview on canonical Wnt signaling and introducing some critical β-Catenin/T-cell factor-target genes, the interaction of canonical Wnt signaling with some common human cancers will be discussed. In the end, the different segments of the aforesaid signaling pathway, which have been considered as targets for clinical purposes, will be scrutinized.</description><identifier>ISSN: 1028-852X</identifier><identifier>EISSN: 2008-823X</identifier><identifier>DOI: 10.29252/ibj.24.5.264</identifier><identifier>PMID: 32429632</identifier><language>eng</language><publisher>Iran: Pasteur Institute of Iran</publisher><subject>Animals ; Bone diseases ; Cancer ; Coronary artery disease ; Frizzled protein ; Gene Expression Regulation, Neoplastic ; Heart diseases ; Homeostasis ; Humans ; Lymphocytes T ; Models, Biological ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - prevention & control ; Neoplasms - therapy ; Neurodegenerative diseases ; Review ; Signal transduction ; Signaling ; Skin diseases ; Transcription factors ; Wnt protein ; Wnt Signaling Pathway - genetics ; β-Catenin</subject><ispartof>Iranian biomedical journal, 2020-09, Vol.24 (5), p.269-275</ispartof><rights>2020. This work is published under https://creativecommons.org/licenses/by-nd/4.0/ (the “License”). 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Box 14155-6455, Tehran, Iran</creatorcontrib><title>The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy</title><title>Iranian biomedical journal</title><addtitle>Iran Biomed J</addtitle><description>Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseases, including cancers, neurodegenerative disorders, skin and bone diseases, and heart deficiencies. Therefore, Wnt/β-Catenin signal transduction is a potential clinical target for the treatment of not only human cancers but also some other human chronic diseases. 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| ispartof | Iranian biomedical journal, 2020-09, Vol.24 (5), p.269-275 |
| issn | 1028-852X 2008-823X |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Bone diseases Cancer Coronary artery disease Frizzled protein Gene Expression Regulation, Neoplastic Heart diseases Homeostasis Humans Lymphocytes T Models, Biological Neoplasms - genetics Neoplasms - metabolism Neoplasms - prevention & control Neoplasms - therapy Neurodegenerative diseases Review Signal transduction Signaling Skin diseases Transcription factors Wnt protein Wnt Signaling Pathway - genetics β-Catenin |
| title | The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy |
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