Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of human infections, and an effective vaccine is critical to mitigate coronavirus-induced disease 2019 (COVID-19). Previously, we developed a replication-competent vesicular stomatitis virus (VSV) expressing a modified...

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Veröffentlicht in:	Cell host & microbe 2020-09, Vol.28 (3), p.465-474.e4
Hauptverfasser:	Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Smith, Brittany K., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Keeler, Shamus P., Bloyet, Louis-Marie, Zhao, Haiyan, Ma, Meisheng, Adams, Lucas J., Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Betacoronavirus - immunology Betacoronavirus - pathogenicity Chlorocebus aethiops Clinical and Translational Report Coronavirus Infections - genetics Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - virology correlates COVID-19 COVID-19 Vaccines Disease Models, Animal Genetic Vectors Green Fluorescent Proteins - genetics Host Microbial Interactions - immunology Humans humoral immunity immunity Life Sciences Life Sciences & Biomedicine Lung - immunology Lung - pathology Lung - virology Mice Mice, Inbred BALB C Mice, Transgenic Microbiology Microbiology and Parasitology neutralizing antibodies Pandemics - prevention & control Parasitology Peptidyl-Dipeptidase A - genetics Pneumonia, Viral - immunology Pneumonia, Viral - prevention & control Pneumonia, Viral - virology Receptors, Virus - genetics SARS-CoV-2 Science & Technology Translational Research, Biomedical vaccine Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology Vero Cells Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis Indiana virus - immunology vesicular stomatitis virus Viral Vaccines - genetics Viral Vaccines - immunology Viral Vaccines - pharmacology Virology
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