Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies

Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies

Alkaline phosphatase (ALP) responsive polymers, which can unzip from head to tail are reported. Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggere...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (60), p.8456-8459
Hauptverfasser: Kumar, Vikash, Munkhbat, Oyuntuya, Secinti, Hatice, Thayumanavan, S
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline phosphatase
Alkaline Phosphatase - metabolism
Dismantling
Enzymes
Hydrophobic and Hydrophilic Interactions
Kinetics
Nanoparticles
Nanoparticles - chemistry
Polyelectrolytes
Polyelectrolytes - chemistry
Polyelectrolytes - metabolism
Polymers
Polymers - chemistry
Polymers - metabolism
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Zusammenfassung:Alkaline phosphatase (ALP) responsive polymers, which can unzip from head to tail are reported. Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggered disassembly kinetics.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03257c