Pravastatin for lowering lipids
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To learn more about the pharmacology of pravastatin by characterizing the dose‐related effect and variability of the effect of pravastatin on the surrogate marker: low‐density lipoprotein (LDL c...
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Veröffentlicht in: | Cochrane database of systematic reviews 2020-07, Vol.2020 (7) |
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creator | Adams, Stephen P Alaeiilkhchi, Nima Tasnim, Sara Wright, James M |
description | This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Primary objective
To learn more about the pharmacology of pravastatin by characterizing the dose‐related effect and variability of the effect of pravastatin on the surrogate marker: low‐density lipoprotein (LDL cholesterol). The effects of statins on morbidity and mortality is not the objective of this systematic review.
Secondary objectives
To characterize the dose‐related effect and variability of effect of pravastatin on the following surrogate markers: total cholesterol; high‐density lipoprotein (HDL cholesterol); and triglycerides.
To quantify the effect of various doses of pravastatin on withdrawals due to adverse effects. |
doi_str_mv | 10.1002/14651858.CD013673 |
format | Article |
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Primary objective
To learn more about the pharmacology of pravastatin by characterizing the dose‐related effect and variability of the effect of pravastatin on the surrogate marker: low‐density lipoprotein (LDL cholesterol). The effects of statins on morbidity and mortality is not the objective of this systematic review.
Secondary objectives
To characterize the dose‐related effect and variability of effect of pravastatin on the following surrogate markers: total cholesterol; high‐density lipoprotein (HDL cholesterol); and triglycerides.
To quantify the effect of various doses of pravastatin on withdrawals due to adverse effects.</description><identifier>ISSN: 1465-1858</identifier><identifier>EISSN: 1465-1858</identifier><identifier>EISSN: 1469-493X</identifier><identifier>DOI: 10.1002/14651858.CD013673</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Heart & circulation ; Treatment of essential Hypertension</subject><ispartof>Cochrane database of systematic reviews, 2020-07, Vol.2020 (7)</ispartof><rights>Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2583-1713b4669d1cc21baca1d29766b9f03d4fe55f5a8675368a22445bd27a8ab6743</citedby><cites>FETCH-LOGICAL-c2583-1713b4669d1cc21baca1d29766b9f03d4fe55f5a8675368a22445bd27a8ab6743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids></links><search><creatorcontrib>Adams, Stephen P</creatorcontrib><creatorcontrib>Alaeiilkhchi, Nima</creatorcontrib><creatorcontrib>Tasnim, Sara</creatorcontrib><creatorcontrib>Wright, James M</creatorcontrib><title>Pravastatin for lowering lipids</title><title>Cochrane database of systematic reviews</title><description>This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Primary objective
To learn more about the pharmacology of pravastatin by characterizing the dose‐related effect and variability of the effect of pravastatin on the surrogate marker: low‐density lipoprotein (LDL cholesterol). The effects of statins on morbidity and mortality is not the objective of this systematic review.
Secondary objectives
To characterize the dose‐related effect and variability of effect of pravastatin on the following surrogate markers: total cholesterol; high‐density lipoprotein (HDL cholesterol); and triglycerides.
To quantify the effect of various doses of pravastatin on withdrawals due to adverse effects.</description><subject>Heart & circulation</subject><subject>Treatment of essential Hypertension</subject><issn>1465-1858</issn><issn>1465-1858</issn><issn>1469-493X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkM1Kw0AUhQdRsFYfwJV5gdT5n8lGkGhVKOhC18PN_NSRNAkzseLba6gVXZ3Dudxv8SF0TvCCYEwvCZeCaKEX9Q0mTCp2gGbTVk7j4Z9-jE5yfsOYyYqqGbp4SrCFPMIYuyL0qWj7D59ity7aOESXT9FRgDb7s5-co5fl7XN9X64e7x7q61VpqdCsJIqwhktZOWItJQ1YII5WSsqmCpg5HrwQQYCWSjCpgVLOReOoAg2NVJzN0dWOO7w3G--s78YErRlS3ED6ND1E8__SxVez7rdGMa00k98AsgPY1OecfPj9JdhMisxekdkrYl-vWFk7</recordid><startdate>20200709</startdate><enddate>20200709</enddate><creator>Adams, Stephen P</creator><creator>Alaeiilkhchi, Nima</creator><creator>Tasnim, Sara</creator><creator>Wright, James M</creator><general>John Wiley & Sons, Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200709</creationdate><title>Pravastatin for lowering lipids</title><author>Adams, Stephen P ; Alaeiilkhchi, Nima ; Tasnim, Sara ; Wright, James M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2583-1713b4669d1cc21baca1d29766b9f03d4fe55f5a8675368a22445bd27a8ab6743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Heart & circulation</topic><topic>Treatment of essential Hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, Stephen P</creatorcontrib><creatorcontrib>Alaeiilkhchi, Nima</creatorcontrib><creatorcontrib>Tasnim, Sara</creatorcontrib><creatorcontrib>Wright, James M</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cochrane database of systematic reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, Stephen P</au><au>Alaeiilkhchi, Nima</au><au>Tasnim, Sara</au><au>Wright, James M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pravastatin for lowering lipids</atitle><jtitle>Cochrane database of systematic reviews</jtitle><date>2020-07-09</date><risdate>2020</risdate><volume>2020</volume><issue>7</issue><issn>1465-1858</issn><eissn>1465-1858</eissn><eissn>1469-493X</eissn><abstract>This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Primary objective
To learn more about the pharmacology of pravastatin by characterizing the dose‐related effect and variability of the effect of pravastatin on the surrogate marker: low‐density lipoprotein (LDL cholesterol). The effects of statins on morbidity and mortality is not the objective of this systematic review.
Secondary objectives
To characterize the dose‐related effect and variability of effect of pravastatin on the following surrogate markers: total cholesterol; high‐density lipoprotein (HDL cholesterol); and triglycerides.
To quantify the effect of various doses of pravastatin on withdrawals due to adverse effects.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/14651858.CD013673</doi><oa>free_for_read</oa></addata></record> |
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identifier | ISSN: 1465-1858 |
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source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cochrane Library; Alma/SFX Local Collection |
subjects | Heart & circulation Treatment of essential Hypertension |
title | Pravastatin for lowering lipids |
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