Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage

Liver failure leads to the massive necrosis of hepatocytes, releasing large amounts of intracellular components including damage-associated molecular patterns (DAMPs). We found that extracellular gp96 levels in serum were elevated in patients with chronic hepatitis B infection (CHB) and acute-on-chr...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.12596-12596, Article 12596
Hauptverfasser:	Guan, Zeliang, Ding, Yun, Liu, Yongai, Zhang, Yu, Zhao, Jingmin, Li, Changfei, Li, Zihai, Meng, Songdong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1933 631/250/256 692/4020/4021/1607 692/4020/4021/1607/234 Adult Animals Chronic infection Concanavalin A Cytokines D-Galactosamine Disease Models, Animal End Stage Liver Disease - immunology End Stage Liver Disease - metabolism Female Glycoprotein gp96 Hepatitis B Hepatocytes Humanities and Social Sciences Humans Inflammation Interferon Kupffer cells Lipopolysaccharides Liver Liver diseases Liver Failure, Acute - immunology Liver Failure, Acute - metabolism Male Membrane Glycoproteins - blood Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Middle Aged multidisciplinary Science Science (multidisciplinary)
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