$Single-agent activity of phosphatidylinositol 3-kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell lymphoma$

Single-agent activity of phosphatidylinositol 3-kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell lymphoma

Patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) have adverse outcomes. We evaluated the efficacy and safety of the phosphatidylinositol 3-kinase inhibitor copanlisib in patients with relapsed/refractory DLBCL and assessed the relationship between efficacy and DLBCL cell of or...

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Veröffentlicht in:	Leukemia 2020-08, Vol.34 (8), p.2184-2197
Hauptverfasser:	Lenz, Georg, Hawkes, Eliza, Verhoef, Gregor, Haioun, Corinne, Thye Lim, Soon, Seog Heo, Dae, Ardeshna, Kirit, Chong, Geoffrey, Haaber, Jacob, Shi, Wei, Gorbatchevsky, Igor, Lippert, Susanne, Hiemeyer, Florian, Piraino, Paolo, Beckmann, Georg, Peña, Carol, Buvaylo, Viktoriya, Childs, Barrett H., Salles, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13 13/51 38 38/23 631/67/1059/602 692/699/67/1990/291/1621/1915 Adult Adverse events Aged Aged, 80 and over B-cell lymphoma Biomarkers Cancer Research Care and treatment CD79 Antigens - genetics Chief operating officers Critical Care Medicine Development and progression Diarrhea Diseases Enzyme inhibitors Female Hematology High-Throughput Nucleotide Sequencing Humans Hyperglycemia Hypertension Intensive Internal Medicine Kinases Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Mutation Non-Hodgkin's lymphomas Oncology Phosphoinositide-3 Kinase Inhibitors - therapeutic use Phospholipids Pyrimidines - adverse effects Pyrimidines - therapeutic use Quinazolines - adverse effects Quinazolines - therapeutic use Recurrence Relapse Safety management Subgroups Vincristine
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