Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples

•Studied incident squamous oral cavity cancers in North America and Western Europe.•Focused on patients with HPV16-negative and p16-negative oral cavity cancers.•A 2-phase study of a 13-gene signature for predicting oral cavity cancer survival.•Compared models with and without the signature for earl...

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Veröffentlicht in:	Oral oncology 2020-01, Vol.100, p.104487-104487, Article 104487
Hauptverfasser:	Chen, Chu, Lohavanichbutr, Pawadee, Zhang, Yuzheng, Houck, John R., Upton, Melissa P., Abedi-Ardekani, Behnoush, Agudo, Antonio, Ahrens, Wolfgang, Alemany, Laia, Anantharaman, Devasena, Conway, David I., Futran, Neal D., Holcatova, Ivana, Günther, Kathrin, Hansen, Bo T., Healy, Claire M., Itani, Doha, Kjaerheim, Kristina, Monroe, Marcus M., Thomson, Peter J., Witt, Benjamin L., Nakoneshny, Steven, Peterson, Lisa A., Schwartz, Stephen M., Zarins, Katie R., Hashibe, Mia, Brennan, Paul, Rozek, Laura S., Wolf, Gregory, Dort, Joseph C., Wang, Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Area Under Curve Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cyclin-Dependent Kinase Inhibitor p16 - metabolism Female Gene Expression Profiling - methods HPV Human papillomavirus 16 - isolation & purification Humans Male Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Staging Oral cancer Oral cavity cancer P16 Paraffin Embedding Prognosis Prognostic gene signature Sequence Analysis, RNA Survival Analysis Tissue Fixation Young Adult
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