Adipose tissue depot‐specific intracellular and extracellular cues contributing to insulin resistance in obese individuals

Adipose tissue dysregulation in obesity strongly influences systemic metabolic homeostasis and is often linked to insulin resistance (IR). However, the molecular mechanisms underlying adipose tissue dysfunction in obesity are not fully understood. Herein, a proteomic analysis of subcutaneous (SC) an...

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Veröffentlicht in:	The FASEB journal 2020-06, Vol.34 (6), p.7520-7539
Hauptverfasser:	Guzmán‐Ruiz, Rocío, Tercero‐Alcázar, Carmen, Rabanal‐Ruiz, Yoana, Díaz‐Ruiz, Alberto, El Bekay, Rajaa, Rangel‐Zuñiga, Oriol A., Navarro‐Ruiz, M. Carmen, Molero, Laura, Membrives, Antonio, Ruiz‐Rabelo, Juan F., Pandit, Abhay, López‐Miranda, José, Tinahones, Francisco J., Malagón, María M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D culture adipocytes Adipocytes - metabolism Adipocytes - pathology Adipogenesis - physiology Adipose Tissue - metabolism Adipose Tissue - pathology Adult Cues extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Guanine Nucleotide Dissociation Inhibitors - metabolism Humans Insulin Resistance - physiology lipid droplets Lumican - metabolism Male Middle Aged Obesity - metabolism Obesity - pathology Proteomics - methods Subcutaneous Fat - metabolism
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