The emerging role of α-synuclein truncation in aggregation and disease

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases, including Parkinson's disease, Lewy body dementia, and multiple system atrophy. These fibrils may induce further αs...

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Veröffentlicht in:	The Journal of biological chemistry 2020-07, Vol.295 (30), p.10224-10244
Hauptverfasser:	Sorrentino, Zachary A., Giasson, Benoit I.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism amyloid Animals fibril Humans inclusion formation JBC Reviews Lewy body Lewy body dementia multiple system atrophy neurodegeneration neurodegenerative disease Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Parkinson's disease post-translational modification post-translational modification (PTM) prion Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - metabolism Protein Aggregation, Pathological - pathology Protein Aggregation, Pathological - therapy truncation α-synuclein
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