Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction

Caloric restriction (CR) is the leading non-pharmaceutical dietary intervention to improve health- and lifespan in most model organisms. A wide array of cellular pathways is induced in response to CR and CR-mimetics, including the transcriptional activator Nuclear factor erythroid-2-related factor 2...

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Veröffentlicht in:	Free radical biology & medicine 2020-05, Vol.152, p.650-658
Hauptverfasser:	Pomatto, Laura C.D., Dill, Theresa, Carboneau, Bethany, Levan, Sophia, Kato, Jonathan, Mercken, Evi M., Pearson, Kevin J., Bernier, Michel, de Cabo, Rafael
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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