Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury
Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney injury (AKI). We aimed to investigate the association between serum iron levels and prognosis in intensive care unit (ICU) patients with AKI....
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| Veröffentlicht in: | BMC nephrology 2020-07, Vol.21 (1), p.303-303, Article 303 |
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| creator | Shu, Jie Hu, Yufeng Yu, Xueshu Chen, Jiaxiu Xu, Wenwei Pan, Jingye |
| description | Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney injury (AKI). We aimed to investigate the association between serum iron levels and prognosis in intensive care unit (ICU) patients with AKI.
A total of 483 patients with AKI defined as per the Kidney Disease: Improving Global Guidelines were included in this retrospective study. The data was extracted from the single-centre Medical Information Mart for Intensive Care III database. AKI patients with serum iron parameters measured upon ICU admission were included and divided into two groups (low group and high group). The prognostic value of serum iron was analysed using univariate and multivariate Cox regression analysis.
The optimal cut-off value for serum iron was calculated to be 60 μg/dl. Univariable Cox regression analysis showed that serum iron levels were significantly correlated with prognosis of AKI patients. After adjusting for possible confounding variables, serum iron levels higher than 60 μg/dl were associated with increases in 28-day (hazard [HR] 1.832; P |
| doi_str_mv | 10.1186/s12882-020-01965-9 |
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A total of 483 patients with AKI defined as per the Kidney Disease: Improving Global Guidelines were included in this retrospective study. The data was extracted from the single-centre Medical Information Mart for Intensive Care III database. AKI patients with serum iron parameters measured upon ICU admission were included and divided into two groups (low group and high group). The prognostic value of serum iron was analysed using univariate and multivariate Cox regression analysis.
The optimal cut-off value for serum iron was calculated to be 60 μg/dl. Univariable Cox regression analysis showed that serum iron levels were significantly correlated with prognosis of AKI patients. After adjusting for possible confounding variables, serum iron levels higher than 60 μg/dl were associated with increases in 28-day (hazard [HR] 1.832; P < 0.001) and 90-day (HR 1.741; P < 0.001) mortality, as per multivariable Cox regression analysis.
High serum iron levels were associated with increased short- and long-term mortality in ICU patients with AKI. Serum iron levels measured upon admission may be used for predicting prognosis in AKI patients.</description><identifier>ISSN: 1471-2369</identifier><identifier>EISSN: 1471-2369</identifier><identifier>DOI: 10.1186/s12882-020-01965-9</identifier><identifier>PMID: 32711469</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acute kidney injury ; Apoptosis ; Cell cycle ; Cell death ; Creatinine ; Critically ill persons ; Health aspects ; Inflammation ; Intensive care ; Iron ; Iron (Nutrient) ; Kidney diseases ; Laboratories ; Medical prognosis ; Mortality ; Nephrology ; Oxidative stress ; Physiological aspects ; Predictor ; Prognosis ; Regression analysis ; Urine</subject><ispartof>BMC nephrology, 2020-07, Vol.21 (1), p.303-303, Article 303</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-13a54d69ae15f3b9573845fc0b3092208c820d4b5c26e48e5ad53780d6237f093</citedby><cites>FETCH-LOGICAL-c563t-13a54d69ae15f3b9573845fc0b3092208c820d4b5c26e48e5ad53780d6237f093</cites><orcidid>0000-0002-2367-1275</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382811/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382811/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32711469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Hu, Yufeng</creatorcontrib><creatorcontrib>Yu, Xueshu</creatorcontrib><creatorcontrib>Chen, Jiaxiu</creatorcontrib><creatorcontrib>Xu, Wenwei</creatorcontrib><creatorcontrib>Pan, Jingye</creatorcontrib><title>Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury</title><title>BMC nephrology</title><addtitle>BMC Nephrol</addtitle><description>Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney injury (AKI). We aimed to investigate the association between serum iron levels and prognosis in intensive care unit (ICU) patients with AKI.
A total of 483 patients with AKI defined as per the Kidney Disease: Improving Global Guidelines were included in this retrospective study. The data was extracted from the single-centre Medical Information Mart for Intensive Care III database. AKI patients with serum iron parameters measured upon ICU admission were included and divided into two groups (low group and high group). The prognostic value of serum iron was analysed using univariate and multivariate Cox regression analysis.
The optimal cut-off value for serum iron was calculated to be 60 μg/dl. Univariable Cox regression analysis showed that serum iron levels were significantly correlated with prognosis of AKI patients. After adjusting for possible confounding variables, serum iron levels higher than 60 μg/dl were associated with increases in 28-day (hazard [HR] 1.832; P < 0.001) and 90-day (HR 1.741; P < 0.001) mortality, as per multivariable Cox regression analysis.
High serum iron levels were associated with increased short- and long-term mortality in ICU patients with AKI. Serum iron levels measured upon admission may be used for predicting prognosis in AKI patients.</description><subject>Acute kidney injury</subject><subject>Apoptosis</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Creatinine</subject><subject>Critically ill persons</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Intensive care</subject><subject>Iron</subject><subject>Iron (Nutrient)</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Predictor</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Urine</subject><issn>1471-2369</issn><issn>1471-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptUstu1DAUjRCIlsIPsECW2LBJ8SN27A1SNSowUiU2dIvl2DdTD4k92Emr-XucTikdhLywfe855z50quotweeESPExEyolrTHFNSZK8Fo9q05J05KaMqGeP3mfVK9y3mJMWtngl9UJoy0hjVCn1Y_LAW7NBA5lSPOIfIoBlRAMyGdk0C6B83aKCcW-fOImxFwSPqD16hrtzOQhTBnd-ekGGTtPgH56F2BfENs57V9XL3ozZHjzcJ9V158vv6--1lffvqxXF1e15YJNNWGGN04oA4T3rFO8ZbLhvcUdw4pSLK2k2DUdt1RAI4Ebx1krsROUtT1W7KxaH3RdNFu9S340aa-j8fo-ENNGmzR5O4DmtnOUdAK6rtRg1jhrKXccG-ksZYvWp4PWbu5GcLYMmMxwJHqcCf5Gb-KtLk1TSUgR-PAgkOKvGfKkR58tDIMJEOesaUNbTjknuEDf_wPdxjmFsqqCYry0Q5n8i9qYMoAPfSx17SKqLwQjCjMil7Ln_0GV42D0NgbofYkfEeiBYFPMOUH_OCPBenGYPjhMF4fpe4fpZTvvnm7nkfLHUuw3BzvKTA</recordid><startdate>20200725</startdate><enddate>20200725</enddate><creator>Shu, Jie</creator><creator>Hu, Yufeng</creator><creator>Yu, Xueshu</creator><creator>Chen, Jiaxiu</creator><creator>Xu, Wenwei</creator><creator>Pan, Jingye</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2367-1275</orcidid></search><sort><creationdate>20200725</creationdate><title>Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury</title><author>Shu, Jie ; Hu, Yufeng ; Yu, Xueshu ; Chen, Jiaxiu ; Xu, Wenwei ; Pan, Jingye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-13a54d69ae15f3b9573845fc0b3092208c820d4b5c26e48e5ad53780d6237f093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute kidney injury</topic><topic>Apoptosis</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Creatinine</topic><topic>Critically ill persons</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Intensive care</topic><topic>Iron</topic><topic>Iron (Nutrient)</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Oxidative stress</topic><topic>Physiological aspects</topic><topic>Predictor</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Hu, Yufeng</creatorcontrib><creatorcontrib>Yu, Xueshu</creatorcontrib><creatorcontrib>Chen, Jiaxiu</creatorcontrib><creatorcontrib>Xu, Wenwei</creatorcontrib><creatorcontrib>Pan, Jingye</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shu, Jie</au><au>Hu, Yufeng</au><au>Yu, Xueshu</au><au>Chen, Jiaxiu</au><au>Xu, Wenwei</au><au>Pan, Jingye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury</atitle><jtitle>BMC nephrology</jtitle><addtitle>BMC Nephrol</addtitle><date>2020-07-25</date><risdate>2020</risdate><volume>21</volume><issue>1</issue><spage>303</spage><epage>303</epage><pages>303-303</pages><artnum>303</artnum><issn>1471-2369</issn><eissn>1471-2369</eissn><abstract>Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney injury (AKI). We aimed to investigate the association between serum iron levels and prognosis in intensive care unit (ICU) patients with AKI.
A total of 483 patients with AKI defined as per the Kidney Disease: Improving Global Guidelines were included in this retrospective study. The data was extracted from the single-centre Medical Information Mart for Intensive Care III database. AKI patients with serum iron parameters measured upon ICU admission were included and divided into two groups (low group and high group). The prognostic value of serum iron was analysed using univariate and multivariate Cox regression analysis.
The optimal cut-off value for serum iron was calculated to be 60 μg/dl. Univariable Cox regression analysis showed that serum iron levels were significantly correlated with prognosis of AKI patients. After adjusting for possible confounding variables, serum iron levels higher than 60 μg/dl were associated with increases in 28-day (hazard [HR] 1.832; P < 0.001) and 90-day (HR 1.741; P < 0.001) mortality, as per multivariable Cox regression analysis.
High serum iron levels were associated with increased short- and long-term mortality in ICU patients with AKI. Serum iron levels measured upon admission may be used for predicting prognosis in AKI patients.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>32711469</pmid><doi>10.1186/s12882-020-01965-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2367-1275</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerOpen; PubMed Central(OpenAccess); DOAJ Directory of Open Access Journals; Springer Nature; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Acute kidney injury Apoptosis Cell cycle Cell death Creatinine Critically ill persons Health aspects Inflammation Intensive care Iron Iron (Nutrient) Kidney diseases Laboratories Medical prognosis Mortality Nephrology Oxidative stress Physiological aspects Predictor Prognosis Regression analysis Urine |
| title | Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury |
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