VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons

Vascular endothelial growth factor-A (VEGF) is the angiogenic factor promoting the pathological neovascularization in age-related macular degeneration (AMD) or diabetic macular edema (DME). Evidences have suggested a neurotrophic and neuroprotective role of VEGF, albeit in retina, cellular mechanism...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.12409-12409, Article 12409
Hauptverfasser:	Froger, Nicolas, Matonti, Frédéric, Roubeix, Christophe, Forster, Valérie, Ivkovic, Ivana, Brunel, Nadège, Baudouin, Christophe, Sahel, José-Alain, Picaud, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2613/1786 692/699/3161/3175 Age Aged Aged, 80 and over Angiogenesis Animals Autocrine Communication - drug effects Autocrine signalling Cell culture Cell Survival - drug effects Cells, Cultured Diabetes mellitus Diabetic Retinopathy - complications Diabetic Retinopathy - drug therapy Edema Female Glaucoma Glaucoma - drug therapy Glaucoma - etiology Glaucoma - pathology Humanities and Social Sciences Humans Intravitreal Injections Life Sciences Macular degeneration Macular Degeneration - complications Macular Degeneration - drug therapy Macular Edema - complications Macular Edema - drug therapy Male Mesenchymal Stem Cells - metabolism Mesenchyme Middle Aged Monoclonal antibodies multidisciplinary Neurons and Cognition Neuroprotection Neutralization Paracrine Communication - drug effects Paracrine signalling Primary Cell Culture Prospective Studies Ranibizumab - administration & dosage Rats Receptors, Vascular Endothelial Growth Factor - administration & dosage Recombinant Fusion Proteins - administration & dosage Recombinant Proteins - genetics Recombinant Proteins - metabolism Retina Retinal ganglion cells Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Science Science (multidisciplinary) Stem cells Traps Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor B - genetics Vascular Endothelial Growth Factor B - metabolism Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular endothelial growth factor receptors Vascularization
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