Long‐term observation of pulmonary toxicity of toner with external additives following a single intratracheal instillation in rats

Objectives Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long‐term observation following intratracheal instillation...

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Veröffentlicht in:	Journal of occupational health 2020-01, Vol.62 (1), p.e12146-n/a
Hauptverfasser:	Tomonaga, Taisuke, Izumi, Hiroto, Yoshiura, Yukiko, Marui, Takashi, Wang, Ke‐Yong, Nishida, Chinatsu, Yatera, Kazuhiro, Morimoto, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Additives Alveoli Animals Bronchoalveolar Lavage Fluid - chemistry Carbon black Carcinogenesis - chemically induced Damage Deoxyribonucleic acid DNA DNA damage Exposure external additives Female Fibrosis Histopathology Inflammation Inhalation Exposure - adverse effects Ink intratracheal instillation Laboratory animals Lung - pathology Lung diseases Lungs Macrophages Nanoparticles Neutrophils Occupational health Original Physiology Pneumonia - chemically induced Polyesters rat Rats Rats, Wistar Rodents Scanning electron microscopy Spleen Technological change Titanium toner Toners Toxicity Trachea Tumorigenesis Tumors Variance analysis VOCs Volatile organic compounds
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