Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells

Circulating tumor cell (CTC)-based liquid biopsies provide unique opportunities for cancer diagnostics, treatment selection, and response monitoring, but even with advanced microfluidic technologies for rare cell detection the very low number of CTCs in standard 10-mL peripheral blood samples limits...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-07, Vol.117 (29), p.16839-16847
Hauptverfasser:	Mishra, Avanish, Dubash, Taronish D., Edd, Jon F., Jewett, Michelle K., Garre, Suhaas G., Karabacak, Nezihi Murat, Rabe, Daniel C., Mutlu, Baris R., Walsh, John R., Kapur, Ravi, Stott, Shannon L., Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological Sciences Blood Blood circulation Blood volume Cancer Channels Depletion Enrichment Epitopes Leukapheresis Leukocytes Leukocytes (mononuclear) Magnetic fields Microfluidics Microlenses Peripheral blood Physical Sciences Rapid flow Solid tumors Tumor cells Tumors
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