Longitudinal changes in symptom‐based female and male LUTS clusters
Aims Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments receiv...
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| Veröffentlicht in: | Neurourology and urodynamics 2020-01, Vol.39 (1), p.393-402 |
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| creator | Amundsen, Cindy L. Helmuth, Margaret E. Smith, Abigail R. DeLancey, John O.L. Bradley, Catherine S. Flynn, Kathryn E. Kenton, Kimberly S. Henry Lai, H. Cella, David Griffith, James W. Andreev, Victor P. Eric Jelovsek, J. Liu, Alice B. Kirkali, Ziya Yang, Claire C. |
| description | Aims
Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.
Methods
Patient‐reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.
Results
Four‐hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: −.04 change in standard deviations of severity scores (ΔSD) to −.67 ΔSD). Prostate surgery was associated with improved severity scores (−.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (−.88 ΔSD) in women.
Conclusion
Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future. |
| doi_str_mv | 10.1002/nau.24219 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381999</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336993436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4439-84f83dae492b2cebfd98034a933bc70050eb9605e53c6e29cf9e984bc1c92493</originalsourceid><addsrcrecordid>eNp1kctKw0AUhgdRbL0sfAEJuNFF2rklk9kIRbxB0IV1PUwmJ3UkmdRMonTnI_iMPompraKCq3PgfHz8nB-hA4JHBGM6drobUU6J3EBDElEcxkKITTTEgrGQ8lgM0I73jxjjhHG5jQaMiDjikgzReVq7mW273DpdBuZBuxn4wLrAL6p5W1fvr2-Z9pAHBVS6hEC7PPhc0vvpXWDKzrfQ-D20VejSw_567qLpxfn07CpMby-vzyZpaDhnMkx4kbBcA5c0owayIpcJZlxLxjIjMI4wZDLGEUTMxEClKSTIhGeGGEm5ZLvodKWdd1kFuQHXNrpU88ZWulmoWlv1--Lsg5rVz0qwhEi5FByvBU391IFvVWW9gbLUDurOK8pIIliURLxHj_6gj3XX9E9aUizuZZzFPXWyokxTe99A8R2GYLXsRvXdqM9uevbwZ_pv8quMHhivgBdbwuJ_k7qZ3K-UH23ImY0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2336993436</pqid></control><display><type>article</type><title>Longitudinal changes in symptom‐based female and male LUTS clusters</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Amundsen, Cindy L. ; Helmuth, Margaret E. ; Smith, Abigail R. ; DeLancey, John O.L. ; Bradley, Catherine S. ; Flynn, Kathryn E. ; Kenton, Kimberly S. ; Henry Lai, H. ; Cella, David ; Griffith, James W. ; Andreev, Victor P. ; Eric Jelovsek, J. ; Liu, Alice B. ; Kirkali, Ziya ; Yang, Claire C.</creator><creatorcontrib>Amundsen, Cindy L. ; Helmuth, Margaret E. ; Smith, Abigail R. ; DeLancey, John O.L. ; Bradley, Catherine S. ; Flynn, Kathryn E. ; Kenton, Kimberly S. ; Henry Lai, H. ; Cella, David ; Griffith, James W. ; Andreev, Victor P. ; Eric Jelovsek, J. ; Liu, Alice B. ; Kirkali, Ziya ; Yang, Claire C. ; LURN Study Group ; the LURN Study Group</creatorcontrib><description>Aims
Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.
Methods
Patient‐reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.
Results
Four‐hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: −.04 change in standard deviations of severity scores (ΔSD) to −.67 ΔSD). Prostate surgery was associated with improved severity scores (−.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (−.88 ΔSD) in women.
Conclusion
Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.24219</identifier><identifier>PMID: 31765491</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Cohort analysis ; lower urinary tract symptoms ; Observational studies ; Patients ; Prostate ; Regression analysis ; Surgery ; symptom‐based clustering ; the Symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort study ; urinary incontinence ; Urinary tract ; Urogenital system</subject><ispartof>Neurourology and urodynamics, 2020-01, Vol.39 (1), p.393-402</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-84f83dae492b2cebfd98034a933bc70050eb9605e53c6e29cf9e984bc1c92493</citedby><cites>FETCH-LOGICAL-c4439-84f83dae492b2cebfd98034a933bc70050eb9605e53c6e29cf9e984bc1c92493</cites><orcidid>0000-0003-2691-994X ; 0000-0002-4750-6258</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnau.24219$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnau.24219$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31765491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amundsen, Cindy L.</creatorcontrib><creatorcontrib>Helmuth, Margaret E.</creatorcontrib><creatorcontrib>Smith, Abigail R.</creatorcontrib><creatorcontrib>DeLancey, John O.L.</creatorcontrib><creatorcontrib>Bradley, Catherine S.</creatorcontrib><creatorcontrib>Flynn, Kathryn E.</creatorcontrib><creatorcontrib>Kenton, Kimberly S.</creatorcontrib><creatorcontrib>Henry Lai, H.</creatorcontrib><creatorcontrib>Cella, David</creatorcontrib><creatorcontrib>Griffith, James W.</creatorcontrib><creatorcontrib>Andreev, Victor P.</creatorcontrib><creatorcontrib>Eric Jelovsek, J.</creatorcontrib><creatorcontrib>Liu, Alice B.</creatorcontrib><creatorcontrib>Kirkali, Ziya</creatorcontrib><creatorcontrib>Yang, Claire C.</creatorcontrib><creatorcontrib>LURN Study Group</creatorcontrib><creatorcontrib>the LURN Study Group</creatorcontrib><title>Longitudinal changes in symptom‐based female and male LUTS clusters</title><title>Neurourology and urodynamics</title><addtitle>Neurourol Urodyn</addtitle><description>Aims
Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.
Methods
Patient‐reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.
Results
Four‐hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: −.04 change in standard deviations of severity scores (ΔSD) to −.67 ΔSD). Prostate surgery was associated with improved severity scores (−.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (−.88 ΔSD) in women.
Conclusion
Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.</description><subject>Cohort analysis</subject><subject>lower urinary tract symptoms</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Prostate</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>symptom‐based clustering</subject><subject>the Symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort study</subject><subject>urinary incontinence</subject><subject>Urinary tract</subject><subject>Urogenital system</subject><issn>0733-2467</issn><issn>1520-6777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kctKw0AUhgdRbL0sfAEJuNFF2rklk9kIRbxB0IV1PUwmJ3UkmdRMonTnI_iMPompraKCq3PgfHz8nB-hA4JHBGM6drobUU6J3EBDElEcxkKITTTEgrGQ8lgM0I73jxjjhHG5jQaMiDjikgzReVq7mW273DpdBuZBuxn4wLrAL6p5W1fvr2-Z9pAHBVS6hEC7PPhc0vvpXWDKzrfQ-D20VejSw_567qLpxfn07CpMby-vzyZpaDhnMkx4kbBcA5c0owayIpcJZlxLxjIjMI4wZDLGEUTMxEClKSTIhGeGGEm5ZLvodKWdd1kFuQHXNrpU88ZWulmoWlv1--Lsg5rVz0qwhEi5FByvBU391IFvVWW9gbLUDurOK8pIIliURLxHj_6gj3XX9E9aUizuZZzFPXWyokxTe99A8R2GYLXsRvXdqM9uevbwZ_pv8quMHhivgBdbwuJ_k7qZ3K-UH23ImY0</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Amundsen, Cindy L.</creator><creator>Helmuth, Margaret E.</creator><creator>Smith, Abigail R.</creator><creator>DeLancey, John O.L.</creator><creator>Bradley, Catherine S.</creator><creator>Flynn, Kathryn E.</creator><creator>Kenton, Kimberly S.</creator><creator>Henry Lai, H.</creator><creator>Cella, David</creator><creator>Griffith, James W.</creator><creator>Andreev, Victor P.</creator><creator>Eric Jelovsek, J.</creator><creator>Liu, Alice B.</creator><creator>Kirkali, Ziya</creator><creator>Yang, Claire C.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2691-994X</orcidid><orcidid>https://orcid.org/0000-0002-4750-6258</orcidid></search><sort><creationdate>202001</creationdate><title>Longitudinal changes in symptom‐based female and male LUTS clusters</title><author>Amundsen, Cindy L. ; Helmuth, Margaret E. ; Smith, Abigail R. ; DeLancey, John O.L. ; Bradley, Catherine S. ; Flynn, Kathryn E. ; Kenton, Kimberly S. ; Henry Lai, H. ; Cella, David ; Griffith, James W. ; Andreev, Victor P. ; Eric Jelovsek, J. ; Liu, Alice B. ; Kirkali, Ziya ; Yang, Claire C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-84f83dae492b2cebfd98034a933bc70050eb9605e53c6e29cf9e984bc1c92493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cohort analysis</topic><topic>lower urinary tract symptoms</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Prostate</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>symptom‐based clustering</topic><topic>the Symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort study</topic><topic>urinary incontinence</topic><topic>Urinary tract</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amundsen, Cindy L.</creatorcontrib><creatorcontrib>Helmuth, Margaret E.</creatorcontrib><creatorcontrib>Smith, Abigail R.</creatorcontrib><creatorcontrib>DeLancey, John O.L.</creatorcontrib><creatorcontrib>Bradley, Catherine S.</creatorcontrib><creatorcontrib>Flynn, Kathryn E.</creatorcontrib><creatorcontrib>Kenton, Kimberly S.</creatorcontrib><creatorcontrib>Henry Lai, H.</creatorcontrib><creatorcontrib>Cella, David</creatorcontrib><creatorcontrib>Griffith, James W.</creatorcontrib><creatorcontrib>Andreev, Victor P.</creatorcontrib><creatorcontrib>Eric Jelovsek, J.</creatorcontrib><creatorcontrib>Liu, Alice B.</creatorcontrib><creatorcontrib>Kirkali, Ziya</creatorcontrib><creatorcontrib>Yang, Claire C.</creatorcontrib><creatorcontrib>LURN Study Group</creatorcontrib><creatorcontrib>the LURN Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurourology and urodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amundsen, Cindy L.</au><au>Helmuth, Margaret E.</au><au>Smith, Abigail R.</au><au>DeLancey, John O.L.</au><au>Bradley, Catherine S.</au><au>Flynn, Kathryn E.</au><au>Kenton, Kimberly S.</au><au>Henry Lai, H.</au><au>Cella, David</au><au>Griffith, James W.</au><au>Andreev, Victor P.</au><au>Eric Jelovsek, J.</au><au>Liu, Alice B.</au><au>Kirkali, Ziya</au><au>Yang, Claire C.</au><aucorp>LURN Study Group</aucorp><aucorp>the LURN Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in symptom‐based female and male LUTS clusters</atitle><jtitle>Neurourology and urodynamics</jtitle><addtitle>Neurourol Urodyn</addtitle><date>2020-01</date><risdate>2020</risdate><volume>39</volume><issue>1</issue><spage>393</spage><epage>402</epage><pages>393-402</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>Aims
Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.
Methods
Patient‐reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.
Results
Four‐hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: −.04 change in standard deviations of severity scores (ΔSD) to −.67 ΔSD). Prostate surgery was associated with improved severity scores (−.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (−.88 ΔSD) in women.
Conclusion
Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31765491</pmid><doi>10.1002/nau.24219</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2691-994X</orcidid><orcidid>https://orcid.org/0000-0002-4750-6258</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurourology and urodynamics, 2020-01, Vol.39 (1), p.393-402 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cohort analysis lower urinary tract symptoms Observational studies Patients Prostate Regression analysis Surgery symptom‐based clustering the Symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort study urinary incontinence Urinary tract Urogenital system |
| title | Longitudinal changes in symptom‐based female and male LUTS clusters |
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