Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

Tuberous sclerosis complex (TSC) is a neurogenetic disorder that leads to elevated mechanistic targeting of rapamycin complex 1 (mTORC1) activity. Cilia can be affected by mTORC1 signaling, and ciliary deficits are associated with neurodevelopmental disorders. Here, we examine whether neuronal cilia...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-06, Vol.31 (12), p.107780-107780, Article 107780
Hauptverfasser:	Di Nardo, Alessia, Lenoël, Isadora, Winden, Kellen D., Rühmkorf, Alina, Modi, Meera E., Barrett, Lee, Ercan-Herbst, Ebru, Venugopal, Pooja, Behne, Robert, Lopes, Carla A.M., Kleiman, Robin J., Bettencourt-Dias, Mónica, Sahin, Mustafa
Format:	Artikel
Sprache:	eng
Schlagworte:	17-AGG Aging - metabolism Animals autism Benzoquinones - pharmacology brain Brain - pathology cilia Cilia - metabolism ciliopathy Down-Regulation - drug effects Heat-Shock Response - drug effects Hsp27 HSP27 Heat-Shock Proteins - metabolism Hsp90 HSP90 Heat-Shock Proteins - metabolism Humans Lactams, Macrocyclic - pharmacology Mechanistic Target of Rapamycin Complex 1 - metabolism Mice, Knockout mTOR Neurons - drug effects Neurons - metabolism Phenotype Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Sirolimus - pharmacology Time Factors TSC Tuberous Sclerosis Complex 1 Protein - metabolism Tuberous Sclerosis Complex 2 Protein - metabolism Up-Regulation - drug effects
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