Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions
BACKGROUND Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c conc...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2019-02, Vol.59 (2), p.454-457 |
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| creator | Prosenz, Julian Öhlinger, Thomas Müllner, Ernst W. Marculescu, Rodrig Gerner, Christopher Salzer, Ulrich Kiefer, Florian W. Baron, David M. |
| description | BACKGROUND
Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c concentrations of RBCs change during the maximum allowed storage period of 42 days.
STUDY DESIGN AND METHODS
Blood was drawn from 16 volunteers, leukofiltered, and stored under standard blood banking conditions. HbA1c concentrations of RBCs were measured on Days 1 and 42 of storage using three different validated devices (ion‐exchange high‐performance liquid chromatography Method A1 and A2, turbidimetric immunoassay Method B).
RESULTS
Mean HbA1c concentrations of RBCs on Day 1 were 5.3 ± 0.3% (Method A1), 5.4 ± 0.4% (Method A2), and 5.1 ± 0.4% (Method B). HbA1c concentrations increased to 5.6 ± 0.3% (A1, p < 0.0001), 5.7 ± 0.3% (A2, p = 0.004), and 5.5 ± 0.4% (B, p < 0.0001) on Day 42, respectively, corresponding to a 1.06‐fold increase across all methods. Glucose concentrations in the storage solution of RBCs decreased from 495 ± 27 to 225 ± 55 mg/dL (p < 0.0001), confirming that stored RBCs were metabolically active.
CONCLUSION
These results suggest a significant, albeit minor, and most likely clinically insignificant increase in HbA1c concentrations during storage of RBCs for 42 days. |
| doi_str_mv | 10.1111/trf.14956 |
| format | Article |
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Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c concentrations of RBCs change during the maximum allowed storage period of 42 days.
STUDY DESIGN AND METHODS
Blood was drawn from 16 volunteers, leukofiltered, and stored under standard blood banking conditions. HbA1c concentrations of RBCs were measured on Days 1 and 42 of storage using three different validated devices (ion‐exchange high‐performance liquid chromatography Method A1 and A2, turbidimetric immunoassay Method B).
RESULTS
Mean HbA1c concentrations of RBCs on Day 1 were 5.3 ± 0.3% (Method A1), 5.4 ± 0.4% (Method A2), and 5.1 ± 0.4% (Method B). HbA1c concentrations increased to 5.6 ± 0.3% (A1, p < 0.0001), 5.7 ± 0.3% (A2, p = 0.004), and 5.5 ± 0.4% (B, p < 0.0001) on Day 42, respectively, corresponding to a 1.06‐fold increase across all methods. Glucose concentrations in the storage solution of RBCs decreased from 495 ± 27 to 225 ± 55 mg/dL (p < 0.0001), confirming that stored RBCs were metabolically active.
CONCLUSION
These results suggest a significant, albeit minor, and most likely clinically insignificant increase in HbA1c concentrations during storage of RBCs for 42 days.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.14956</identifier><identifier>PMID: 30727042</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Banking ; Brief Report ; Brief Reports ; Diabetes mellitus ; Erythrocytes ; Hemoglobin ; Immunoassay ; Liquid chromatography</subject><ispartof>Transfusion (Philadelphia, Pa.), 2019-02, Vol.59 (2), p.454-457</ispartof><rights>2018 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.</rights><rights>2019 AABB</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-32b048369ab7a9f273699f5c340c0f9aba986640ee6bd5bdef48511660f1d4ff3</citedby><cites>FETCH-LOGICAL-c4436-32b048369ab7a9f273699f5c340c0f9aba986640ee6bd5bdef48511660f1d4ff3</cites><orcidid>0000-0003-1509-7127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.14956$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.14956$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30727042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prosenz, Julian</creatorcontrib><creatorcontrib>Öhlinger, Thomas</creatorcontrib><creatorcontrib>Müllner, Ernst W.</creatorcontrib><creatorcontrib>Marculescu, Rodrig</creatorcontrib><creatorcontrib>Gerner, Christopher</creatorcontrib><creatorcontrib>Salzer, Ulrich</creatorcontrib><creatorcontrib>Kiefer, Florian W.</creatorcontrib><creatorcontrib>Baron, David M.</creatorcontrib><title>Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND
Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c concentrations of RBCs change during the maximum allowed storage period of 42 days.
STUDY DESIGN AND METHODS
Blood was drawn from 16 volunteers, leukofiltered, and stored under standard blood banking conditions. HbA1c concentrations of RBCs were measured on Days 1 and 42 of storage using three different validated devices (ion‐exchange high‐performance liquid chromatography Method A1 and A2, turbidimetric immunoassay Method B).
RESULTS
Mean HbA1c concentrations of RBCs on Day 1 were 5.3 ± 0.3% (Method A1), 5.4 ± 0.4% (Method A2), and 5.1 ± 0.4% (Method B). HbA1c concentrations increased to 5.6 ± 0.3% (A1, p < 0.0001), 5.7 ± 0.3% (A2, p = 0.004), and 5.5 ± 0.4% (B, p < 0.0001) on Day 42, respectively, corresponding to a 1.06‐fold increase across all methods. Glucose concentrations in the storage solution of RBCs decreased from 495 ± 27 to 225 ± 55 mg/dL (p < 0.0001), confirming that stored RBCs were metabolically active.
CONCLUSION
These results suggest a significant, albeit minor, and most likely clinically insignificant increase in HbA1c concentrations during storage of RBCs for 42 days.</description><subject>Banking</subject><subject>Brief Report</subject><subject>Brief Reports</subject><subject>Diabetes mellitus</subject><subject>Erythrocytes</subject><subject>Hemoglobin</subject><subject>Immunoassay</subject><subject>Liquid chromatography</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kUtrFTEYhoMo9lhd-Ack4EYX0-Y2yWQjSGmrUBCkrkMml9PUTFKTGeWs-tfN6bRFBbPJ7cmb7_1eAF5jdITbOJ6LP8JM9vwJ2OCeio5I2T8FG4QY7jCm5AC8qPUaIUQkws_BAUWCCMTIBtyex53Rs7Pwyk15G_MYEjQ5GZfmoueQU4XZw9KAMeZsoXExVjiFFCYd4w6GZIrT1UG7lJC2sM656K2DS7KutJ1OVpeHx6NO3_dQ-8CGO_GX4JnXsbpX9_Mh-HZ2ennyqbv4cv755ONFZxijvKNkRGygXOpRaOmJaEvpe0MZMsi3Uy0Hzhlyjo-2H63zbOgx5hx5bJn39BB8WHVvlnFydrUX1U1pNspOZR3U3zcpXKlt_qkEFZIMpAm8uxco-cfi6qymUPfN0MnlpSpCWm-HgfZDQ9_-g17npaRmTxEsOCNSINGo9ytlSq61OP9YDEZqH6tqsaq7WBv75s_qH8mHHBtwvAK_QnS7_yupy69nq-RvdZmv0g</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Prosenz, Julian</creator><creator>Öhlinger, Thomas</creator><creator>Müllner, Ernst W.</creator><creator>Marculescu, Rodrig</creator><creator>Gerner, Christopher</creator><creator>Salzer, Ulrich</creator><creator>Kiefer, Florian W.</creator><creator>Baron, David M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1509-7127</orcidid></search><sort><creationdate>201902</creationdate><title>Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions</title><author>Prosenz, Julian ; Öhlinger, Thomas ; Müllner, Ernst W. ; Marculescu, Rodrig ; Gerner, Christopher ; Salzer, Ulrich ; Kiefer, Florian W. ; Baron, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-32b048369ab7a9f273699f5c340c0f9aba986640ee6bd5bdef48511660f1d4ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Banking</topic><topic>Brief Report</topic><topic>Brief Reports</topic><topic>Diabetes mellitus</topic><topic>Erythrocytes</topic><topic>Hemoglobin</topic><topic>Immunoassay</topic><topic>Liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prosenz, Julian</creatorcontrib><creatorcontrib>Öhlinger, Thomas</creatorcontrib><creatorcontrib>Müllner, Ernst W.</creatorcontrib><creatorcontrib>Marculescu, Rodrig</creatorcontrib><creatorcontrib>Gerner, Christopher</creatorcontrib><creatorcontrib>Salzer, Ulrich</creatorcontrib><creatorcontrib>Kiefer, Florian W.</creatorcontrib><creatorcontrib>Baron, David M.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prosenz, Julian</au><au>Öhlinger, Thomas</au><au>Müllner, Ernst W.</au><au>Marculescu, Rodrig</au><au>Gerner, Christopher</au><au>Salzer, Ulrich</au><au>Kiefer, Florian W.</au><au>Baron, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2019-02</date><risdate>2019</risdate><volume>59</volume><issue>2</issue><spage>454</spage><epage>457</epage><pages>454-457</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>BACKGROUND
Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c concentrations of RBCs change during the maximum allowed storage period of 42 days.
STUDY DESIGN AND METHODS
Blood was drawn from 16 volunteers, leukofiltered, and stored under standard blood banking conditions. HbA1c concentrations of RBCs were measured on Days 1 and 42 of storage using three different validated devices (ion‐exchange high‐performance liquid chromatography Method A1 and A2, turbidimetric immunoassay Method B).
RESULTS
Mean HbA1c concentrations of RBCs on Day 1 were 5.3 ± 0.3% (Method A1), 5.4 ± 0.4% (Method A2), and 5.1 ± 0.4% (Method B). HbA1c concentrations increased to 5.6 ± 0.3% (A1, p < 0.0001), 5.7 ± 0.3% (A2, p = 0.004), and 5.5 ± 0.4% (B, p < 0.0001) on Day 42, respectively, corresponding to a 1.06‐fold increase across all methods. Glucose concentrations in the storage solution of RBCs decreased from 495 ± 27 to 225 ± 55 mg/dL (p < 0.0001), confirming that stored RBCs were metabolically active.
CONCLUSION
These results suggest a significant, albeit minor, and most likely clinically insignificant increase in HbA1c concentrations during storage of RBCs for 42 days.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30727042</pmid><doi>10.1111/trf.14956</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-1509-7127</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Banking Brief Report Brief Reports Diabetes mellitus Erythrocytes Hemoglobin Immunoassay Liquid chromatography |
| title | Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions |
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