Integrated genetic, epigenetic, and gene set enrichment analyses identify NOTCH as a potential mediator for PTSD risk after trauma: Results from two independent African cohorts

The risk of developing posttraumatic stress disorder (PTSD) increases with the number of traumatic event types experienced (trauma load) in interaction with other psychobiological risk factors. The NOTCH (neurogenic locus notch homolog proteins) signaling pathway, consisting of four different trans‐...

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Veröffentlicht in:	Psychophysiology 2020-01, Vol.57 (1), p.e13288-n/a
Hauptverfasser:	Conrad, Daniela, Wilker, Sarah, Schneider, Anna, Karabatsiakis, Alexander, Pfeiffer, Anett, Kolassa, Stephan, Freytag, Virginie, Vukojevic, Vanja, Vogler, Christian, Milnik, Annette, Papassotiropoulos, Andreas, J.‐F. de Quervain, Dominique, Elbert, Thomas, Kolassa, Iris‐Tatjana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult candidate gene analysis Cell interactions Cell signaling Cohort Studies CpG Islands DNA methylation DNA Methylation - genetics DNA microarrays Environmental factors Epigenesis, Genetic - genetics epigenetics Event-related potentials gene set enrichment analysis Genetic analysis Genetic and Epigenetic Associations with Trauma Exposure Genetic diversity Humans Inflammation MAGMA Nerve Tissue Proteins - genetics NOTCH Notch1 protein Notch3 protein Polymorphism, Single Nucleotide Post traumatic stress disorder posttraumatic stress disorder Psychological Trauma - complications Receptor, Notch3 - genetics Risk Risk factors Rwanda Saliva Signal transduction Signal Transduction - genetics Single-nucleotide polymorphism Stress Disorders, Post-Traumatic - etiology Stress Disorders, Post-Traumatic - genetics Trauma Uganda
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