Decreased salivary lactoferrin levels are specific to Alzheimer's disease
Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients. To assess the clinical utilit...
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| Veröffentlicht in: | EBioMedicine 2020-07, Vol.57, p.102834-102834, Article 102834 |
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| creator | González-Sánchez, Marta Bartolome, Fernando Antequera, Desiree Puertas-Martín, Veronica González, Pilar Gómez-Grande, Adolfo Llamas-Velasco, Sara Herrero-San Martín, Alejandro Pérez-Martínez, David Villarejo-Galende, Alberto Atienza, Mercedes Palomar-Bonet, Miriam Cantero, Jose Luis Perry, George Orive, Gorka Ibañez, Borja Bueno, Hector Fuster, Valentin Carro, Eva |
| description | Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients.
To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.
The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911–0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET+) versus healthy group, and 0•97 (0•924–1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0•93 (0•876–0•989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity.
Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.
Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B. |
| doi_str_mv | 10.1016/j.ebiom.2020.102834 |
| format | Article |
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To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.
The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911–0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET+) versus healthy group, and 0•97 (0•924–1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0•93 (0•876–0•989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity.
Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.
Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B.</description><identifier>ISSN: 2352-3964</identifier><identifier>EISSN: 2352-3964</identifier><identifier>DOI: 10.1016/j.ebiom.2020.102834</identifier><identifier>PMID: 32586758</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alzheimer´s disease ; Biomarkers ; Frontotemporal dementia ; Lactoferrin ; Pet imaging ; Research paper ; Saliva</subject><ispartof>EBioMedicine, 2020-07, Vol.57, p.102834-102834, Article 102834</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</rights><rights>2020 The Authors 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-15419d92f7b97691df284359ed911009ab20054cdbc0a4cd911bc0e652c709413</citedby><cites>FETCH-LOGICAL-c595t-15419d92f7b97691df284359ed911009ab20054cdbc0a4cd911bc0e652c709413</cites><orcidid>0000-0001-9322-8933 ; 0000-0002-7925-8826 ; 0000-0002-6504-4579 ; 0000-0001-9155-1438</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378957/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378957/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32586758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Sánchez, Marta</creatorcontrib><creatorcontrib>Bartolome, Fernando</creatorcontrib><creatorcontrib>Antequera, Desiree</creatorcontrib><creatorcontrib>Puertas-Martín, Veronica</creatorcontrib><creatorcontrib>González, Pilar</creatorcontrib><creatorcontrib>Gómez-Grande, Adolfo</creatorcontrib><creatorcontrib>Llamas-Velasco, Sara</creatorcontrib><creatorcontrib>Herrero-San Martín, Alejandro</creatorcontrib><creatorcontrib>Pérez-Martínez, David</creatorcontrib><creatorcontrib>Villarejo-Galende, Alberto</creatorcontrib><creatorcontrib>Atienza, Mercedes</creatorcontrib><creatorcontrib>Palomar-Bonet, Miriam</creatorcontrib><creatorcontrib>Cantero, Jose Luis</creatorcontrib><creatorcontrib>Perry, George</creatorcontrib><creatorcontrib>Orive, Gorka</creatorcontrib><creatorcontrib>Ibañez, Borja</creatorcontrib><creatorcontrib>Bueno, Hector</creatorcontrib><creatorcontrib>Fuster, Valentin</creatorcontrib><creatorcontrib>Carro, Eva</creatorcontrib><title>Decreased salivary lactoferrin levels are specific to Alzheimer's disease</title><title>EBioMedicine</title><addtitle>EBioMedicine</addtitle><description>Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients.
To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.
The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911–0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET+) versus healthy group, and 0•97 (0•924–1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0•93 (0•876–0•989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity.
Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.
Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B.</description><subject>Alzheimer´s disease</subject><subject>Biomarkers</subject><subject>Frontotemporal dementia</subject><subject>Lactoferrin</subject><subject>Pet imaging</subject><subject>Research paper</subject><subject>Saliva</subject><issn>2352-3964</issn><issn>2352-3964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UU1LAzEQDaKoaH-BIHvTS2s-NrvJQUHqJwhe9ByyyaymZDc12Rb015vaKnrxNMObN28e8xA6InhCMKnOZhNoXOgmFNMVQgUrt9A-ZZyOmazK7V_9HhqlNMMYE15mUOyiPUa5qGou9tH9FZgIOoEtkvZuqeN74bUZQgsxur7wsASfCh2hSHMwrnWmGEJx6T9ewXUQT1JhXVoJHKKdVvsEo009QM8310_Tu_HD4-399PJhbLjkwzibINJK2taNrCtJbEtFybgEKwnBWOqGYsxLYxuDdS4ZzR1UnJoay5KwA3Sx1p0vmg6sgX6I2qt5dF02r4J26u-kd6_qJSxVzWoheZ0FTjcCMbwtIA2qc8mA97qHsEiKlkQQIpgUmcrWVBNDShHanzMEq1UOaqa-clCrHNQ6h7x1_Nvhz8731zPhfE3Ir4Wlg6iScdAbsC6CGZQN7t8DnznCmls</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>González-Sánchez, Marta</creator><creator>Bartolome, Fernando</creator><creator>Antequera, Desiree</creator><creator>Puertas-Martín, Veronica</creator><creator>González, Pilar</creator><creator>Gómez-Grande, Adolfo</creator><creator>Llamas-Velasco, Sara</creator><creator>Herrero-San Martín, Alejandro</creator><creator>Pérez-Martínez, David</creator><creator>Villarejo-Galende, Alberto</creator><creator>Atienza, Mercedes</creator><creator>Palomar-Bonet, Miriam</creator><creator>Cantero, Jose Luis</creator><creator>Perry, George</creator><creator>Orive, Gorka</creator><creator>Ibañez, Borja</creator><creator>Bueno, Hector</creator><creator>Fuster, Valentin</creator><creator>Carro, Eva</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9322-8933</orcidid><orcidid>https://orcid.org/0000-0002-7925-8826</orcidid><orcidid>https://orcid.org/0000-0002-6504-4579</orcidid><orcidid>https://orcid.org/0000-0001-9155-1438</orcidid></search><sort><creationdate>20200701</creationdate><title>Decreased salivary lactoferrin levels are specific to Alzheimer's disease</title><author>González-Sánchez, Marta ; 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We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients.
To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.
The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911–0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET+) versus healthy group, and 0•97 (0•924–1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0•93 (0•876–0•989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity.
Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.
Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32586758</pmid><doi>10.1016/j.ebiom.2020.102834</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9322-8933</orcidid><orcidid>https://orcid.org/0000-0002-7925-8826</orcidid><orcidid>https://orcid.org/0000-0002-6504-4579</orcidid><orcidid>https://orcid.org/0000-0001-9155-1438</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alzheimer´s disease Biomarkers Frontotemporal dementia Lactoferrin Pet imaging Research paper Saliva |
| title | Decreased salivary lactoferrin levels are specific to Alzheimer's disease |
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