Laboratory mice born to wild mice have natural microbiota and model human immune responses

Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by divergent microbiota and limited translational research value. To address both shortcomings, we transferred C57BL/6 embryos into wild mice, creat...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-08, Vol.365 (6452), p.461-461
Hauptverfasser:	Rosshart, Stephan P., Herz, Jasmin, Vassallo, Brian G., Hunter, Ashli, Wall, Morgan K., Badger, Jonathan H., McCulloch, John A., Anastasakis, Dimitrios G., Sarshad, Aishe A., Leonardi, Irina, Collins, Nicholas, Blatter, Joshua A., Han, Seong-Ji, Tamoutounour, Samira, Potapova, Svetlana, St. Claire, Mark B. Foster, Yuan, Wuxing, Sen, Shurjo K., Dreier, Matthew S., Hild, Benedikt, Hafner, Markus, Wang, David, Iliev, Iliyan D., Belkaid, Yasmine, Trinchieri, Giorgio, Rehermann, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animal models Animals Animals, Wild - microbiology Antibiotics Bacteria Blood CD28 antigen Cell activation Clinical trials Cytokines Cytometry Diet Embryos Endotoxemia Environmental conditions Fc receptors Feedback (Response) Fusion protein Gastrointestinal Microbiome Gene sequencing Genetics Genomes Genotype & phenotype Host Microbial Interactions - immunology Host-Pathogen Interactions - immunology Human behavior Human response Humans Immune system Immunity Immunology Immunoregulation Inbreeding Inflammatory diseases Innate immunity Intestinal microflora Laboratories Lymphocytes Lymphocytes T Mammals Medical research Medical treatment Metabolism Mice Mice, Inbred C57BL Microbiota Microorganisms Models, Animal Neurodegenerative diseases Neurological diseases Organs Pathogens Phenotypes Physiology Reproducibility RESEARCH ARTICLE SUMMARY Research facilities Ribonucleic acid RNA Rodents Septic shock Skin Spleen Translation Translational Medical Research - standards Tumor necrosis factor-TNF Vagina
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