Promoting crystallization of intrinsic membrane proteins with conjugated micelles

A new technique for promoting nucleation and growth of membrane protein (MP) crystals from micellar environments is reported. It relies on the conjugation of micelles that sequester MPs in protein detergent complexes (PDCs). Conjugation via amphiphilic [metal:chelator] complexes presumably takes pla...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.12199-12199, Article 12199
Hauptverfasser:	Van Truong, Thien, Ghosh, Mihir, Wachtel, Ellen, Friedman, Noga, Jung, Kwang-Hwan, Sheves, Mordechai, Patchornik, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	631/535/1258 631/535/1266 Bacteriorhodopsin Bacteriorhodopsins - chemistry Chelating Agents - chemistry Crystal growth Crystallization Crystallization - methods Crystals Ferrous Compounds - chemistry Humanities and Social Sciences Integral membrane proteins Ionic strength Iron Micelles multidisciplinary Nickel - chemistry Nucleation Science Science (multidisciplinary) Thioglucosides - chemistry Zinc Zinc - chemistry
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