Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis
We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast ca...
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| Veröffentlicht in: | Breast (Edinburgh) 2020-02, Vol.49, p.70-73 |
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| creator | Ben-David, Merav A. Corn, Benjamin W. Evron, Ella Goldberg, Hadassah Pfeffer, Raphael M. Abdah-Bortnyak, Roxoliana Matceyevsky, Dianna Weinstein, Yuliana Golan, Orit Sklair-Levy, Miri |
| description | We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer.
For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.
Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group.
Reduction of BPE by PBI may contribute to its prophylactic effect.
•It has been reported that high BPE correlates with the risk of breast cancer.•We previously showed that PBI reduces the risk of breast cancer in BRCA carriers.•Secondary analysis of that trial reveals that PBI reduces BPE in BRCA carriers.•Larger trials are needed to prove correlation with breast cancer risk reduction. |
| doi_str_mv | 10.1016/j.breast.2019.10.011 |
| format | Article |
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For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.
Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group.
Reduction of BPE by PBI may contribute to its prophylactic effect.
•It has been reported that high BPE correlates with the risk of breast cancer.•We previously showed that PBI reduces the risk of breast cancer in BRCA carriers.•Secondary analysis of that trial reveals that PBI reduces BPE in BRCA carriers.•Larger trials are needed to prove correlation with breast cancer risk reduction.</description><identifier>ISSN: 0960-9776</identifier><identifier>EISSN: 1532-3080</identifier><identifier>DOI: 10.1016/j.breast.2019.10.011</identifier><identifier>PMID: 31734591</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>BPE ; BRCA ; Breast cancer ; Prophylactic breast irradiation ; Short Communication</subject><ispartof>Breast (Edinburgh), 2020-02, Vol.49, p.70-73</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2019 The Authors 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-d845a0200041567be8bd9c813ca7ddb5db435b7878af89ff27d10e4dfe29069f3</citedby><cites>FETCH-LOGICAL-c529t-d845a0200041567be8bd9c813ca7ddb5db435b7878af89ff27d10e4dfe29069f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375590/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.breast.2019.10.011$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31734591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben-David, Merav A.</creatorcontrib><creatorcontrib>Corn, Benjamin W.</creatorcontrib><creatorcontrib>Evron, Ella</creatorcontrib><creatorcontrib>Goldberg, Hadassah</creatorcontrib><creatorcontrib>Pfeffer, Raphael M.</creatorcontrib><creatorcontrib>Abdah-Bortnyak, Roxoliana</creatorcontrib><creatorcontrib>Matceyevsky, Dianna</creatorcontrib><creatorcontrib>Weinstein, Yuliana</creatorcontrib><creatorcontrib>Golan, Orit</creatorcontrib><creatorcontrib>Sklair-Levy, Miri</creatorcontrib><title>Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis</title><title>Breast (Edinburgh)</title><addtitle>Breast</addtitle><description>We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer.
For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.
Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group.
Reduction of BPE by PBI may contribute to its prophylactic effect.
•It has been reported that high BPE correlates with the risk of breast cancer.•We previously showed that PBI reduces the risk of breast cancer in BRCA carriers.•Secondary analysis of that trial reveals that PBI reduces BPE in BRCA carriers.•Larger trials are needed to prove correlation with breast cancer risk reduction.</description><subject>BPE</subject><subject>BRCA</subject><subject>Breast cancer</subject><subject>Prophylactic breast irradiation</subject><subject>Short Communication</subject><issn>0960-9776</issn><issn>1532-3080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kU2P0zAQQC0EYkvhHyDk43JIseM4jjkgLasFKi1iheBsTexJ65LExU5X6r_HJcvCXjhZGs-8-XiEvORsxRmv3-xWbURI06pkXOfQinH-iCy4FGUhWMMekwXTNSu0UvUZeZbSjjGmRd08JWeCK1FJzRdkuIlhvz32YCdv6UykPkZwHiYfRhrRHSwm2oL9sYnhMDq6h4ij3R4H6CmOWxgtDjhO9Pz9zdVrmms-f12_pRc0oQ2jg3ikMEJ_TD49J0866BO-uHuX5PuHq2-Xn4rrLx_XlxfXhZWlngrXVBJYmeetuKxVi03rtG24sKCca6VrKyFb1agGukZ3XakcZ1i5DkvNat2JJVnPXBdgZ_bRD3kKE8Cb34EQNwZiXrhHIzhwIWtA3slKaQSGCrQSyFndaSYy693M2h_aAZ3Nm0boH0Af_ox-azbh1iihpMyEJTm_A8Tw84BpMoNPFvseRgyHZErBZZZWlVVOreZUG0NKEbv7NpyZk3WzM7Mjc7J-imbruezVvyPeF_3R_HcHzEe_9RhNsj47ROcj2ilfxf-_wy9LPcF-</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Ben-David, Merav A.</creator><creator>Corn, Benjamin W.</creator><creator>Evron, Ella</creator><creator>Goldberg, Hadassah</creator><creator>Pfeffer, Raphael M.</creator><creator>Abdah-Bortnyak, Roxoliana</creator><creator>Matceyevsky, Dianna</creator><creator>Weinstein, Yuliana</creator><creator>Golan, Orit</creator><creator>Sklair-Levy, Miri</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200201</creationdate><title>Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis</title><author>Ben-David, Merav A. ; Corn, Benjamin W. ; Evron, Ella ; Goldberg, Hadassah ; Pfeffer, Raphael M. ; Abdah-Bortnyak, Roxoliana ; Matceyevsky, Dianna ; Weinstein, Yuliana ; Golan, Orit ; Sklair-Levy, Miri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-d845a0200041567be8bd9c813ca7ddb5db435b7878af89ff27d10e4dfe29069f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>BPE</topic><topic>BRCA</topic><topic>Breast cancer</topic><topic>Prophylactic breast irradiation</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben-David, Merav A.</creatorcontrib><creatorcontrib>Corn, Benjamin W.</creatorcontrib><creatorcontrib>Evron, Ella</creatorcontrib><creatorcontrib>Goldberg, Hadassah</creatorcontrib><creatorcontrib>Pfeffer, Raphael M.</creatorcontrib><creatorcontrib>Abdah-Bortnyak, Roxoliana</creatorcontrib><creatorcontrib>Matceyevsky, Dianna</creatorcontrib><creatorcontrib>Weinstein, Yuliana</creatorcontrib><creatorcontrib>Golan, Orit</creatorcontrib><creatorcontrib>Sklair-Levy, Miri</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Breast (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben-David, Merav A.</au><au>Corn, Benjamin W.</au><au>Evron, Ella</au><au>Goldberg, Hadassah</au><au>Pfeffer, Raphael M.</au><au>Abdah-Bortnyak, Roxoliana</au><au>Matceyevsky, Dianna</au><au>Weinstein, Yuliana</au><au>Golan, Orit</au><au>Sklair-Levy, Miri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis</atitle><jtitle>Breast (Edinburgh)</jtitle><addtitle>Breast</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>49</volume><spage>70</spage><epage>73</epage><pages>70-73</pages><issn>0960-9776</issn><eissn>1532-3080</eissn><abstract>We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer.
For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.
Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group.
Reduction of BPE by PBI may contribute to its prophylactic effect.
•It has been reported that high BPE correlates with the risk of breast cancer.•We previously showed that PBI reduces the risk of breast cancer in BRCA carriers.•Secondary analysis of that trial reveals that PBI reduces BPE in BRCA carriers.•Larger trials are needed to prove correlation with breast cancer risk reduction.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>31734591</pmid><doi>10.1016/j.breast.2019.10.011</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | BPE BRCA Breast cancer Prophylactic breast irradiation Short Communication |
| title | Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis |
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