Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19

The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patients with diagnosed COVID-19 admitted to 9 hospitals from Decem...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-10, Vol.76 (4), p.1104-1112
Hauptverfasser:	Qin, Juan-Juan, Cheng, Xu, Zhou, Feng, Lei, Fang, Akolkar, Gauri, Cai, Jingjing, Zhang, Xiao-Jing, Blet, Alice, Xie, Jing, Zhang, Peng, Liu, Ye-Mao, Huang, Zizhen, Zhao, Ling-Ping, Lin, Lijin, Xia, Meng, Chen, Ming-Ming, Song, Xiaohui, Bai, Liangjie, Chen, Ze, Zhang, Xingyuan, Xiang, Da, Chen, Jing, Xu, Qingbo, Ma, Xinliang, Touyz, Rhian M., Gao, Chen, Wang, Haitao, Liu, Liming, Mao, Weiming, Luo, Pengcheng, Yan, Youqin, Ye, Ping, Chen, Manhua, Chen, Guohua, Zhu, Lihua, She, Zhi-Gang, Huang, Xiaodong, Yuan, Yufeng, Zhang, Bing-Hong, Wang, Yibin, Liu, Peter P., Li, Hongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - isolation & purification Biomarkers - blood China - epidemiology Coronavirus Infections - blood Coronavirus Infections - mortality Coronavirus Infections - therapy COVID-19 Creatine Kinase, MB Form - blood Female Heart Diseases - blood Heart Diseases - mortality Heart Diseases - virology Hospitalization - statistics & numerical data Humans Male Middle Aged Mortality Natriuretic Peptide, Brain - blood Original Outcome Assessment, Health Care Pandemics Peptide Fragments - blood Pneumonia, Viral - blood Pneumonia, Viral - mortality Pneumonia, Viral - therapy Predictive Value of Tests Prognosis Retrospective Studies SARS-CoV-2 Troponin I - blood
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Zusammenfassung:	The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patients with diagnosed COVID-19 admitted to 9 hospitals from December 31, 2019 to March 4, 2020, to estimate the associations and prognostic power of circulating cardiac injury markers with the poor outcomes of COVID-19. In the mixed-effects Cox model, after adjusting for age, sex, and comorbidities, the adjusted hazard ratio of 28-day mortality for hs-cTnI (high-sensitivity cardiac troponin I) was 7.12 ([95% CI, 4.60–11.03] P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.120.15528