UGT2B17 modifies drug response in chronic lymphocytic leukaemia

Background High UGT2B17 is associated with poor prognosis in untreated chronic lymphocytic leukaemia (CLL) patients and its expression is induced in non-responders to fludarabine-containing regimens. We examined whether UGT2B17, the predominant lymphoid glucuronosyltransferase, affects leukaemic dru...

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Veröffentlicht in:	British journal of cancer 2020-07, Vol.123 (2), p.240-251
Hauptverfasser:	Allain, Eric P., Rouleau, Michèle, Vanura, Katrina, Tremblay, Sophie, Vaillancourt, Joanie, Bat, Vincent, Caron, Patrick, Villeneuve, Lyne, Labriet, Adrien, Turcotte, Véronique, Le, Trang, Shehata, Medhat, Schnabl, Susanne, Demirtas, Dita, Hubmann, Rainer, Joly-Beauparlant, Charles, Droit, Arnaud, Jäger, Ulrich, Staber, Philipp B., Lévesque, Eric, Guillemette, Chantal
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028 692/53/2423 692/699/1541/1990 Adenine - adverse effects Adenine - analogs & derivatives Adenine - pharmacology AMP AMP-activated protein kinase Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacology B-Lymphocytes - drug effects B-Lymphocytes - pathology Biomarkers, Pharmacological - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Cell culture Chronic lymphocytic leukemia Cytotoxicity Drug Resistance Epidemiology Female Fludarabine Gene expression Gene Expression Regulation, Neoplastic - drug effects Glucuronosyltransferase Glucuronosyltransferase - genetics Humans Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphocytes B Male Mass Spectrometry Middle Aged Minor Histocompatibility Antigens - genetics Molecular Medicine NF-kappa B - genetics Oncology Piperidines - adverse effects Piperidines - pharmacology Purines - adverse effects Purines - pharmacology Quinazolinones - adverse effects Quinazolinones - pharmacology Ribonucleic acid RNA Targeted cancer therapy Transcriptomes Vidarabine - adverse effects Vidarabine - analogs & derivatives Vidarabine - pharmacology
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