Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization

Aims Remimazolam is a new, ultra‐short‐acting benzodiazepine developed for intravenous (IV) use during procedural sedation and in general anaesthesia. Two trials were conducted to characterize its effects on cardiac repolarization. Methods A thorough QT/QTc (TQT) study assessed electrocardiography e...

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Veröffentlicht in:	British journal of clinical pharmacology 2020-08, Vol.86 (8), p.1600-1609
Hauptverfasser:	Kleiman, Robert B., Darpo, Borje, Thorn, Michael, Stoehr, Thomas, Schippers, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	intravenous drug administration, QT interval, QT‐RR hysteresis Original
Online-Zugang:	Volltext
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