Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition

In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents more than half of the protein-coding capacity of Drosophila melanogaster’s genome, and that 2% of this proteome is rapidly deg...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-06, Vol.31 (12), p.107783-107783, Article 107783
Hauptverfasser:	Cao, Wen Xi, Kabelitz, Sarah, Gupta, Meera, Yeung, Eyan, Lin, Sichun, Rammelt, Christiane, Ihling, Christian, Pekovic, Filip, Low, Timothy C.H., Siddiqui, Najeeb U., Cheng, Matthew H.K., Angers, Stephane, Smibert, Craig A., Wühr, Martin, Wahle, Elmar, Lipshitz, Howard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cup Down-Regulation - genetics Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryo, Nonmammalian - metabolism embryogenesis Embryonic Development - genetics Female Gene Expression Regulation, Developmental ME31B Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Biosynthesis - genetics Protein Subunits - metabolism Proteolysis proteome Proteome - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleoproteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding Smaug Time Factors Trailer hitch Transcription, Genetic Transcriptome - genetics Ubiquitin - metabolism ubiquitin ligase Zygote - metabolism
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