Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors

Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-es...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.11933, Article 11933
Hauptverfasser:	Kim, Ha-Neui, Ponte, Filipa, Nookaew, Intawat, Ucer Ozgurel, Serra, Marques-Carvalho, Adriana, Iyer, Srividhya, Warren, Aaron, Aykin-Burns, Nukhet, Krager, Kimberly, Sardao, Vilma A., Han, Li, de Cabo, Rafael, Zhao, Haibo, Jilka, Robert L., Manolagas, Stavros C., Almeida, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol 631/443/63 631/45/776/812 631/80/82/23 692/163/2743/316/801 Adenosine Triphosphate - biosynthesis Animals Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Biomarkers Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bone Density Bone loss Bone mass Cell Count Cell Differentiation Cells, Cultured Electron transport chain Estrogens Estrogens - metabolism Estrogens - pharmacology FasL protein Female Gene Expression Regulation - drug effects Humanities and Social Sciences Menopause Mice Mice, Knockout Mitochondria Mitochondria - drug effects Mitochondria - metabolism Monocyte-Macrophage Precursor Cells - cytology Monocyte-Macrophage Precursor Cells - drug effects Monocyte-Macrophage Precursor Cells - metabolism multidisciplinary Osteoclastogenesis Osteoclasts Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects Osteoporosis Osteoprogenitor cells Ovariectomy Oxidative Phosphorylation Oxygen consumption Phosphorylation Rotenone Science Science (multidisciplinary) Signal Transduction
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