Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1 H NMR, 13 C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer (NSCLC) A549 cells in a dos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2020-07, Vol.11 (7), p.551, Article 551
Hauptverfasser:	Lin, ZhaoMin, Wang, ZhaoYang, Zhou, XueWen, Zhang, Ming, Gao, DongFang, Zhang, Lu, Wang, Peng, Chen, Yuan, Lin, YuXing, Zhao, BaoXiang, Miao, JunYing, Kong, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/309/555 631/80/39 A549 Cells Animals Antibodies Antineoplastic drugs Antitumor agents Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chick Embryo Chorioallantoic membrane Drug development Endothelial cells Fluorescence Fluorouracil - pharmacology Humans Immunology Inhibitory Concentration 50 Life Sciences Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Lysosomes - drug effects Lysosomes - metabolism Non-small cell lung carcinoma Phagocytosis Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Small cell lung carcinoma Structure-Activity Relationship Tacrolimus Binding Protein 1A - metabolism Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!